Print Email Facebook Twitter Dairy products and pancreatic cancer risk: A pooled analysis of 14 cohort studies Title Dairy products and pancreatic cancer risk: A pooled analysis of 14 cohort studies Author Genkinger, J.M. Wang, M. Li, R. Albanes, D. Anderson, K.E. Bernstein, L. van den Brandt, P.A. English, D.R. Freudenheim, J.L. Fuchs, C.S. Gapstur, S.M. Giles, G.G. Goldbohm, R.A. Håkansson, N. Horn-Ross, P.L. Koushik, A. Marshal, J.R. McCullough, M.L. Miller, A.B. Robien, K. Rohan, T.E. Schairer, C. Silverman, D.T. Stolzenberg-Solomon, R.Z. Virtamo, J. Willett, W.C. Wolk, A. Ziegler, R.G. Smith-Warner, S.A. Publication year 2014 Abstract Pancreatic cancer has few early symptoms, is usually diagnosed at late stages, and has a high case-fatality rate. Identifying modifiable risk factors is crucial to reducing pancreatic cancer morbidity and mortality. Prior studies have suggested that specific foods and nutrients, such as dairy products and constituents, may play a role in pancreatic carcinogenesis. In this pooled analysis of the primary data from 14 prospective cohort studies, 2212 incident pancreatic cancer cases were identified during follow-up among 862 680 individuals. Adjusting for smoking habits, personal history of diabetes, alcohol intake, body mass index (BMI), and energy intake, multivariable study-specific hazard ratios (MVHR) and 95% confidence intervals (CIs) were calculated using the Cox proportional hazards models and then pooled using a random effects model. There was no association between total milk intake and pancreatic cancer risk (MVHR = 0.98, 95% CI = 0.82-1.18 comparing ≥500 with 1-69.9 g/day). Similarly, intakes of low-fat milk, whole milk, cheese, cottage cheese, yogurt, and icecream were not associated with pancreatic cancer risk. No statistically significant association was observed between dietary (MVHR = 0.96, 95% CI = 0.77-1.19) and total calcium (MVHR = 0.89, 95% CI = 0.71-1.12) intake and pancreatic cancer risk overall when comparing intakes ≥1300 with <500 mg/day. In addition, null associations were observed for dietary and total vitamin D intake and pancreatic cancer risk. Findings were consistent within sex, smoking status, and BMI strata or when the case definition was limited to pancreatic adenocarcinoma. Overall, these findings do not support the hypothesis that consumption of dairy foods, calcium, or vitamin D during adulthood is associated with pancreatic cancer risk. © The Author 2014. Published by Oxford University Press on behalf of the European Society for Medical Oncology. All rights reserved. Subject Behavioural ChangesLS - Life StyleELSS - Earth, Life and Social SciencesHealthy for LifeHealthHealthy LivingCalcium intakeDairy productsPancreatic cancerPooled analysisVitamin DYoghurtAdolescentAdultAgedBody massCancer riskCheeseCohort analysisFemaleFood intakeHumanIce creamMajor clinical studyMaleMilkPancreas adenocarcinomaRisk assessmentRisk factorSexSmokingVery elderlyVitamin intake To reference this document use: http://resolver.tudelft.nl/uuid:1a46a61e-040d-4682-b3a8-07b91682a3d3 DOI https://doi.org/10.1093/annonc/mdu019 TNO identifier 513343 ISSN 1569-8041 Source Annals of Oncology, 25 (6), 1106-1115 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.