Title
Concentration-time mortality response relationship of irritant and systemically acting vapours and gases
Author
Centraal Instituut voor Voedingsonderzoek TNO
ten Berge, W.F.
Zwart, A.
Appelman, L.M.
Publication year
1986
Abstract
This report presents the re-evaluation of the raw data of previously published acute inhalation toxicity studies of some volatile industrial chemicals. In these studies both concentration and exposure time were varied. The raw data were obtained from an extensive literature search and were subjected to probit analysis. The results show that the product of concentration and exposure time (ct) is not always a good parameter for predicting the mortality response (Haber's rule). On the contrary, the term c(n)t, in which the exponent n is different from 1, often predicts the response very well. This report presents the re-evaluation of the raw data of previously published acute inhalation toxicity studies of some volatile industrial chemicals. In these studies both concentration and exposure time were varied. The raw data were obtained from an extensive literature search and were subjected to probit analysis. The results show that the product of concentration and exposure time (ct) is not always a good parameter for predicting the mortality response (Haber's rule). On the contrary, the term c**nt, in which the exponent n is different from 1, often predicts the response very well.
Subject
Gases
Risk studies
Health Risks
Vapors
Concentratioen
Time mortality reponse
Irritant
Systemically acting vapors
Chemicals
chemical agent
irritant agent
blood and hemopoietic system
central nervous system
classification
clinical article
concentration
controlled study
diagnosis
education
epidemiology
intoxication
mortality
nonhuman
organization and management
preliminary communication
prevention
To reference this document use:
http://resolver.tudelft.nl/uuid:1a2a78ec-547d-46f8-a662-cf0b7514d0ef
DOI
https://doi.org/10.1016/0304-3894(86)85003-8
TNO identifier
230165
ISSN
0304-3894
Source
Journal of Hazardous Materials, 13 (13), 301-309
Document type
article