Food matrix effects on bioaccessibility of β-carotene can be measured in an in vitro gastrointestinal model

Food matrix effects on bioaccessibility of β-carotene can be measured in an in vitro gastrointestinal model

van Loo-Bouwman, C.A.
Naber, T.H.J.
Minekus, M.
van Breemen, R.B.
Hulshof, P.J.M.
Schaafsma, G.

2014

Since the food matrix determines β-carotene availability for intestinal absorption, food matrix effects on the bioaccessibility of β-carotene from two diets were investigated in vitro and compared with in vivo data. The "mixed diet" consisted of β-carotene-rich vegetables, and the "oil diet" contained β-carotene-low vegetables with supplemental β-carotene. The application of extrinsically labeled β-carotene was also investigated. The bioaccessibility of β-carotene was 28 μg/100 μg β-carotene from the mixed diet and 53 μg/100 μg β-carotene from the oil diet. This ratio of 1.9:1 was consistent with in vivo data, where the apparent absorption was 1.9-fold higher in the oil diet than in the mixed diet. The labeled β-carotene was not equally distributed over time. In conclusion, the food matrix effects on bioaccessibility of β-carotene could be measured using an in vitro model and were consistent with in vivo data. The application of extrinsically labeled β-carotene was not confirmed. © 2014 American Chemical Society.

Life
PHS - Pharmacokinetics & Human Studies
ELSS - Earth, Life and Social Sciences
Food and Nutrition
Biology
Healthy Living
β-carotene
Bioaccessibility
Food matrix
In vitro digestion

http://resolver.tudelft.nl/uuid:1353b805-3d7e-4269-b224-59f5d789d223

https://doi.org/10.1021/jf403312v

489134

0021-8561

Journal of Agricultural and Food Chemistry, 62 (4), 950-955

article