Print Email Facebook Twitter Towards understanding molecular modes of probiotic action Title Towards understanding molecular modes of probiotic action Author Marco, M.L. Pavan, S. Kleerebezem, M. TNO Kwaliteit van Leven Publication year 2006 Abstract The possibility that certain microorganisms might be beneficial to human health is highlighted by the numerous consumer products containing probiotic bacteria. Probiotics are typically administered in food that, following entry into the gastro-intestinal tract, results in measurable health-promoting effects. Although there is a growing list of health benefits provided by the consumption of probiotics, their precise mechanisms of action remain largely unknown. Recent molecular- and genomics-based studies are starting to provide insight into the ways probiotic bacteria sense and adapt to the gastro-intestinal tract environment. Complementary approaches using host cell in vitro systems together with animal models and human volunteers are revealing specific intestinal cell responses to probiotics. These studies should ultimately disclose the molecular mechanisms and pinpoint the bacterial and host effector molecules and pathways by which probiotics are able to modulate human health. © 2006 Elsevier Ltd. All rights reserved. Subject BiologyBiomedical ResearchCellsConsumer productsFood productsGenesHealth careAnimal modelsHost effector moleculesProbiotic bacteriaMicroorganismsprobiotic agentbacterial colonizationbacterial strainbacterial survivalbacterium adherencedendritic cellDNA microarrayfollow upfood biotechnologyhost resistancehumanimmunomodulationinfection preventionintestine floraLactobacillus acidophilusLactobacillus caseinonhumannutrigenomicspriority journalreviewwild typeAnimalsHumansIntestinal MucosaProbioticsAnimaliaBacteria (microorganisms) To reference this document use: http://resolver.tudelft.nl/uuid:13301951-084f-4c0f-841c-8e48177b4ce2 DOI https://doi.org/10.1016/j.copbio.2006.02.005 TNO identifier 239186 ISSN 0958-1669 Source Current Opinion in Biotechnology, 17 (2), 204-210 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.