Print Email Facebook Twitter Job strain as a risk factor for coronary heart disease: A collaborative meta-analysis of individual participant data Title Job strain as a risk factor for coronary heart disease: A collaborative meta-analysis of individual participant data Author Kivimäki, M. Nyberg, S.T. Batty, G.D. Fransson, E.I. Heikkilä, K. Alfredsson, L. Bjorner, J.B. Borritz, M. Burr, H. Casini, A. Clays, E. de Bacquer, D. Dragano, N. Ferrie, J.E. Geuskens, G.A. Goldberg, M. Hamer, M. Hooftman, W.E. Houtman, I.L. Joensuu, M. Jokela, M. Kittel, F. Knutsson, A. Koskenvuo, M. Koskinen, A. Kouvonen, A. Kumari, M. Madsen, I.E.H. Marmot, M.G. Nielsen, M.L. Nordin, M. Oksanen, T. Pentti, J. Rugulies, R. Salo, P. Siegrist, J. Singh-Manoux, A. Suominen, S.B. Väänänen, A. Vahtera, J. Virtanen, M. Westerholm, P.J.M. Westerlund, H. Zins, M. Steptoe, A. Theorell, T. Publication year 2012 Abstract Background Published work assessing psychosocial stress (job strain) as a risk factor for coronary heart disease is inconsistent and subject to publication bias and reverse causation bias. We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies. Methods We used individual records from 13 European cohort studies (1985-2006) of men and women without coronary heart disease who were employed at time of baseline assessment. We measured job strain with questions from validated job-content and demand-control questionnaires. We extracted data in two stages such that acquisition and harmonisation of job strain measure and covariables occurred before linkage to records for coronary heart disease. We defined incident coronary heart disease as the first non-fatal myocardial infarction or coronary death. Findings 30 214 (15%) of 197 473 participants reported job strain. In 1•49 million person-years at risk (mean follow-up 7•5 years [SD 1•7]), we recorded 2358 events of incident coronary heart disease. After adjustment for sex and age, the hazard ratio for job strain versus no job strain was 1•23 (95% CI 1•10-1•37). This effect estimate was higher in published (1•43, 1•15-1•77) than unpublished (1•16, 1•02-1•32) studies. Hazard ratios were likewise raised in analyses addressing reverse causality by exclusion of events of coronary heart disease that occurred in the first 3 years (1•31, 1•15-1•48) and 5 years (1•30, 1•13-1•50) of follow-up. We noted an association between job strain and coronary heart disease for sex, age groups, socioeconomic strata, and region, and after adjustments for socioeconomic status, and lifestyle and conventional risk factors. The population attributable risk for job strain was 3•4%. Interpretation Our findings suggest that prevention of workplace stress might decrease disease incidence; however, this strategy would have a much smaller effect than would tackling of standard risk factors, such as smoking. Funding Finnish Work Environment Fund, the Academy of Finland, the Swedish Research Council for Working Life and Social Research, the German Social Accident Insurance, the Danish National Research Centre for the Working Environment, the BUPA Foundation, the Ministry of Social Affairs and Employment, the Medical Research Council, the Wellcome Trust, and the US National Institutes of Health. Subject OrganisationWH - Work & HealthBSS - Behavioural and Societal SciencesWork and EmploymentWorkplaceHealthy Living To reference this document use: http://resolver.tudelft.nl/uuid:1303ab65-0472-4cd6-8970-173bad6da82e DOI https://doi.org/10.1016/s0140-6736(12)60994-5 TNO identifier 465844 ISSN 0140-6736 Source The Lancet, 380 (9852), 1491-1497 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.