Print Email Facebook Twitter Macrophage migration inhibitory factor: Critical role in obesity, insulin resistance, and associated comorbidities. Title Macrophage migration inhibitory factor: Critical role in obesity, insulin resistance, and associated comorbidities. Author Kleemann, R. Bucala, R. TNO Kwaliteit van Leven Publication year 2010 Abstract Obesity is associated with insulin resistance, disturbed glucose homeostasis, low grade inflammation, and comorbidities such as type 2 diabetes and cardiovascular disease. The cytokine macrophage migration inhibitory factor (MIF) is an ubiquitously expressed protein that plays a crucial role in many inflammatory and autoimmune disorders. Increasing evidence suggests that MIF also controls metabolic and inflammatory processes underlying the development of metabolic pathologies associated with obesity. This is a comprehensive summary of our current knowledge on the role of MIF in obesity and obesity-associated comorbidities, based on human clinical data as well as animal models of disease. Subject Biologyglucosemacrophage migration inhibition factoranimalgeneticshumaninsulin resistancemetabolismobesityphysiologyreviewAnimalsGlucoseHumansInsulin ResistanceMacrophage Migration-Inhibitory FactorsObesity To reference this document use: http://resolver.tudelft.nl/uuid:120fae44-2cca-4e9c-aa0d-b65d787d90d5 TNO identifier 352044 ISSN 1466-1861 Source Mediators of inflammation, 2010, 610479 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.