Print Email Facebook Twitter Comparing the Advanced REACH Tool's (ART) estimates with Switzerland's occupational exposure data Title Comparing the Advanced REACH Tool's (ART) estimates with Switzerland's occupational exposure data Author Savic, N. Gasic, B. Schinkel, J. Vernez, D. Publication year 2018 Abstract The Advanced REACH Tool (ART) is the most sophisticated tool used for evaluating exposure levels under the European Union's Registration, Evaluation, Authorisation and restriction of CHemicals (REACH) regulations. ART provides estimates at different percentiles of exposure and within different confidence intervals (CIs). However, its performance has only been tested on a limited number of exposure data. The present study compares ART's estimates with exposure measurements collected over many years in Switzerland. Measurements from 584 cases of exposure to vapours, mists, powders, and abrasive dusts (wood/stone and metal) were extracted from a Swiss database. The corresponding exposures at the 50th and 90th percentiles were calculated in ART. To characterize the model's performance, the 90% CI of the estimates was considered. ART's performance at the 50th percentile was only found to be insufficiently conservative with regard to exposure to wood/stone dusts, whereas the 90th percentile showed sufficient conservatism for all the types of exposure processed. However, a trend was observed with the residuals, where ART overestimated lower exposures and underestimated higher ones. The median was more precise, however, and the majority (≥60%) of real-world measurements were within a factor of 10 from ART's estimates. We provide recommendations based on the results and suggest further, more comprehensive, investigations. © The Author 2017. Subject LifeRAPID - Risk Analysis for Products in DevelopmentELSS - Earth, Life and Social SciencesBiomedical InnovationHealthy LivingAdvanced REACH ToolModel performance and validationOccupational exposure models50th percentilesConfidence intervalEuropean unionExposure levelExposure measurementModel performanceOccupational exposureREACHDust To reference this document use: http://resolver.tudelft.nl/uuid:10e290b8-e0ed-42fd-97c2-aeedd2d74857 DOI https://doi.org/10.1093/annweh/wxx069 TNO identifier 788259 ISSN 2398-7308 Source Annals of Work Exposures and Health, 61 (8), 954-964 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.