Title
IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans
Author
Albertini, R.J.
Anderson, D.
Douglas, G.R.
Hagmar, L.
Hemminki, K.
Merlo, F.
Natarajan, A.T.
Norppa, H.
Shuker, D.E.G.
Tice, R.
Waters, M.D.
Aitio, A.
TNO Kwaliteit van Leven TNO Bibra
Publication year
2000
Abstract
The purpose of these guidelines is to provide concise guidance on the planning, performing and interpretation of studies to monitor groups or individuals exposed to genotoxic agents. Most human carcinogens are genotoxic but not all genotoxic agents have been shown to be carcinogenic in humans. Although the main interest in these studies is due to the association of genotoxicity with carcinogenicity, there is also an inherent interest in monitoring human genotoxicity independently of cancer as an endpoint.The most often studied genotoxicity endpoints have been selected for inclusion in this document and they are structural and numerical chromosomal aberrations assessed using cytogenetic methods (classical chromosomal aberration analysis (CA), fluorescence in situ hybridisation (FISH), micronuclei (MN)); DNA damage (adducts, strand breaks, crosslinking, alkali-labile sites) assessed using bio-chemical/electrophoretic assays or sister chromatid exchanges (SCE); protein adducts; and hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutations. The document does not consider germ cells or gene mutation assays other than HPRT or markers of oxidative stress, which have been applied on a more limited scale. Copyright (C) 2000 Elsevier Science B.V.
Subject
Biomarkers
Biomonitoring
Genotoxic carcinogens
Guideline
Human populations
WHO
carcinogen
hypoxanthine phosphoribosyltransferase
blood analysis
carcinogenicity
chromosome aberration
comet assay
cytogenetics
DNA adduct
DNA damage
ethics
fluorescence in situ hybridization
gene mutation
genotoxicity
human
micronucleus test
patient monitoring
practice guideline
priority journal
protein binding
review
risk assessment
sampling
sister chromatid exchange
statistical analysis
technique
Carcinogens
Chromosome Aberrations
DNA Damage
Environmental Health
Environmental Monitoring
Humans
Hypoxanthine Phosphoribosyltransferase
In Situ Hybridization, Fluorescence
International Cooperation
Lymphocytes
Micronucleus Tests
Mutagens
Sister Chromatid Exchange
Toxicity Tests
United Nations
World Health Organization
To reference this document use:
http://resolver.tudelft.nl/uuid:10d67fc5-fa40-41e4-b75f-32db29556492
DOI
https://doi.org/10.1016/s1383-5742(00)00049-1
TNO identifier
280413
ISSN
1383-5742
Source
Mutation Research - Reviews in Mutation Research, 463 (2), 111-172
Document type
article