Print Email Facebook Twitter IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans Title IPCS guidelines for the monitoring of genotoxic effects of carcinogens in humans Author Albertini, R.J. Anderson, D. Douglas, G.R. Hagmar, L. Hemminki, K. Merlo, F. Natarajan, A.T. Norppa, H. Shuker, D.E.G. Tice, R. Waters, M.D. Aitio, A. TNO Kwaliteit van Leven TNO Bibra Publication year 2000 Abstract The purpose of these guidelines is to provide concise guidance on the planning, performing and interpretation of studies to monitor groups or individuals exposed to genotoxic agents. Most human carcinogens are genotoxic but not all genotoxic agents have been shown to be carcinogenic in humans. Although the main interest in these studies is due to the association of genotoxicity with carcinogenicity, there is also an inherent interest in monitoring human genotoxicity independently of cancer as an endpoint.The most often studied genotoxicity endpoints have been selected for inclusion in this document and they are structural and numerical chromosomal aberrations assessed using cytogenetic methods (classical chromosomal aberration analysis (CA), fluorescence in situ hybridisation (FISH), micronuclei (MN)); DNA damage (adducts, strand breaks, crosslinking, alkali-labile sites) assessed using bio-chemical/electrophoretic assays or sister chromatid exchanges (SCE); protein adducts; and hypoxanthine-guanine phosphoribosyltransferase (HPRT) mutations. The document does not consider germ cells or gene mutation assays other than HPRT or markers of oxidative stress, which have been applied on a more limited scale. Copyright (C) 2000 Elsevier Science B.V. Subject BiomarkersBiomonitoringGenotoxic carcinogensGuidelineHuman populationsWHOcarcinogenhypoxanthine phosphoribosyltransferaseblood analysiscarcinogenicitychromosome aberrationcomet assaycytogeneticsDNA adductDNA damageethicsfluorescence in situ hybridizationgene mutationgenotoxicityhumanmicronucleus testpatient monitoringpractice guidelinepriority journalprotein bindingreviewrisk assessmentsamplingsister chromatid exchangestatistical analysistechniqueCarcinogensChromosome AberrationsDNA DamageEnvironmental HealthEnvironmental MonitoringHumansHypoxanthine PhosphoribosyltransferaseIn Situ Hybridization, FluorescenceInternational CooperationLymphocytesMicronucleus TestsMutagensSister Chromatid ExchangeToxicity TestsUnited NationsWorld Health Organization To reference this document use: http://resolver.tudelft.nl/uuid:10d67fc5-fa40-41e4-b75f-32db29556492 DOI https://doi.org/10.1016/s1383-5742(00)00049-1 TNO identifier 280413 ISSN 1383-5742 Source Mutation Research - Reviews in Mutation Research, 463 (2), 111-172 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.