Print Email Facebook Twitter The effect of alcohol consumption on insulin sensitivity and glycemic status: A systematic review and meta-analysis of intervention studies Title The effect of alcohol consumption on insulin sensitivity and glycemic status: A systematic review and meta-analysis of intervention studies Author Schrieks, I.C. Heil, A.L. Hendriks, H.F. Mukamal, K.J. Beulens, J.W. Publication year 2015 Abstract OBJECTIVE: Moderate alcohol consumption is associated with a reduced risk of type 2 diabetes. This reduced risk might be explained by improved insulin sensitivity or improved glycemic status, but results of intervention studies on this relation are inconsistent. The purpose of this study was to conduct a systematic review and meta-analysis of intervention studies investigating the effect of alcohol consumption on insulin sensitivity and glycemic status. RESEARCH DESIGN AND METHODS: PubMed and Embase were searched up to August 2014. Intervention studies on the effect of alcohol consumption on biological markers of insulin sensitivity or glycemic status of at least 2 weeks' duration were included. Investigators extracted data on study characteristics, outcome measures, and methodological quality. RESULTS: Fourteen intervention studies were included in a meta-analysis of six glycemic end points. Alcohol consumption did not influence estimated insulin sensitivity (standardized mean difference [SMD] 0.08 [-0.09 to 0.24]) or fasting glucose (SMD 0.07 [-0.11 to 0.24]) but reduced HbA1c (SMD -0.62 [-1.01 to -0.23]) and fasting insulin concentrations (SMD -0.19 [-0.35 to -0.02]) compared with the control condition. Alcohol consumption among women reduced fasting insulin (SMD -0.23 [-0.41 to -0.04]) and tended to improve insulin sensitivity (SMD 0.16 [-0.04 to 0.37]) but not among men. Results were similar after excluding studies with high alcohol dosages (>40 g/day) and were not influenced by dosage and duration of the intervention. CONCLUSIONS: Although the studies had small sample sizes and were of short duration, the current evidence suggests that moderate alcohol consumption may decrease fasting insulin and HbA1c concentrations among nondiabetic subjects. Alcohol consumption might improve insulin sensitivity among women but did not do so overall. © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered. Chemicals/CAS: alcohol, 64-17-5; insulin, 9004-10-8; Blood Glucose; Ethanol; Insulin Subject LifeMSB - Microbiology and Systems BiologyELSS - Earth, Life and Social SciencesFood and NutritionBiologyHealthy LivingAlcoholBloodClinical trial (topic)Diabetes Mellitus, Type 2Drinking behaviorDrug effectsGlucose blood levelMeta analysisMetabolismMiddle agedStatistics and numerical dataAdultAlcohol DrinkingBlood GlucoseClinical Trials as TopicDiabetes Mellitus, Type 2EthanolFemaleHumansInsulinInsulin ResistanceMaleMiddle AgedYoung Adult To reference this document use: http://resolver.tudelft.nl/uuid:0c2c9ab9-f097-4db6-9191-920b25a5e4ec DOI https://doi.org/10.2337/dc14-1556 TNO identifier 528423 ISSN 1935-5548 Source Diabetes care, 38 (4), 723-732 Article number 25805864 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.