Print Email Facebook Twitter Histopathologic approaches to detect changes indicative of immunotoxicity Title Histopathologic approaches to detect changes indicative of immunotoxicity Author Kuper, C.F. Harleman, J.H. Richter-Reichelm, H.B. Vos, J.G. Centraal Instituut voor Voedingsonderzoek TNO Publication year 2000 Abstract Toxicologic pathology is crucial in the identification and characterization of health effects following exposure to xenobiotics, mainly in toxicity experiments in rodents. Regarding regulatory toxicology, histopathology of lymphoid organs and tissues is a cornerstone in the identification of immunotoxic compounds. A 2-tier testing system is usually employed in which the first tier is a general screen for (immuno)toxicity and the second tier consists of specific immune function studies, including host resistance tests or mechanistic studies. The role attributed to histopathology of lymphoid organs in the updated Organization for Economic Cooperation and Development and Food and Drug Administration guidelines requires improvement and standardization of the histopathology procedures. Optimalization and standardization was started in an international collaborative immunotoxicity study (ICICIS). However, several problems were left unaddressed, mostly because of the few compounds tested in this study. Based on the results of the ICICIS study and the morphologic changes induced by immunotoxic/immunomodulatory compounds observed in other investigations, suggestions are given to further improve the identification and (semi)quantification of histopathologic changes in lymphoid organs and tissues. Chemicals/CAS: Immunosuppressive Agents; Immunotoxins Subject ImmunomodulationImmunosuppressionLymph nodeLymphoid organsMorphologyMucosa-associated lymphoid tissue (MALT)SpleenThymusAnimal tissueCell structureHistopathologyImmunomodulationImmunotoxicityLymph nodeLymphoid organLymphoid tissueNonhumanPriority journalReviewSpleenThymusAnimalsFemaleImmune SystemImmunosuppressive AgentsImmunotoxinsLymphoid TissueMaleRatsAnimaliaRodentia To reference this document use: http://resolver.tudelft.nl/uuid:0c16588e-b230-4ed8-9911-03a6ee2a531e TNO identifier 87181 ISSN 0192-6233 Source Toxicologic Pathology, 28 (3), 454-466 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.