Title
Hyphenation of infrared spectroscopy to liquid chromatography for qualitative and quantitative polymer analysis: Degradation of poly(bisphenol A)carbonate
Author
Coulier, L.
Kaal, E.
Hankemeier, T.
TNO Kwaliteit van Leven
Publication year
2006
Abstract
Hyphenation of infrared spectroscopy (IR) to liquid chromatography (LC) has been applied to study chemical changes in poly(bisphenol A)carbonate (PC) as a result of degradation. Especially coupling of LC to FTIR through solvent elimination is a sensitive approach to identify changes in functionality observed in the LC chromatograms as has been demonstrated by coupling of liquid chromatography under critical conditions (LCCC) to IR. Furthermore, an example is shown in which two-dimensional liquid chromatography, i.e. LCCC × SEC, was coupled to IR by means of a flow cell. This resulted in data sets containing most probably valuable data, but extracting relevant information from these large data sets is not straightforward at all. Therefore, multivariate data analysis (MVDA) of SEC-FTIR data was used to extract relevant data from large data sets. This approach revealed chemical differences due to degradation that could not be detected by other means. Spectral features could be identified that allowed to quantitatively predict the degradation of poly(bisphenol A)carbonate as a function of degradation conditions. © 2006 Elsevier B.V. All rights reserved.
Subject
Biology
Analytical research
Degradation
Infrared spectroscopy
LCCC
Liquid chromatography
Multivariate data analysis
Poly(bisphenol A)carbonate
SEC
Two-dimensional liquid chromatography
LCCC
Multivariate data analysis
Poly(bisphenol A)carbonate
SEC
Two-dimensional liquid chromatography
Data reduction
Degradation
Fourier transform infrared spectroscopy
Infrared spectroscopy
Liquid chromatography
Phenols
Polycarbonates
4,4' isopropylidenediphenol
carbonic acid
poly(bisphenol A)carbonate
polymer
unclassified drug
article
degradation kinetics
infrared spectrophotometry
infrared spectroscopy
liquid chromatography
multivariate analysis
priority journal
separation technique
Chromatography, Liquid
Multivariate Analysis
Polymers
Spectrophotometry, Infrared
To reference this document use:
http://resolver.tudelft.nl/uuid:0b36c99f-064f-44c9-852a-bf94d42e6d9f
DOI
https://doi.org/10.1016/j.chroma.2006.04.070
TNO identifier
239542
ISSN
0021-9673
Source
Journal of Chromatography A, 1130 (1 SPEC. ISS.), 34-42
Document type
article