Print Email Facebook Twitter Hyphenation of infrared spectroscopy to liquid chromatography for qualitative and quantitative polymer analysis: Degradation of poly(bisphenol A)carbonate Title Hyphenation of infrared spectroscopy to liquid chromatography for qualitative and quantitative polymer analysis: Degradation of poly(bisphenol A)carbonate Author Coulier, L. Kaal, E. Hankemeier, T. TNO Kwaliteit van Leven Publication year 2006 Abstract Hyphenation of infrared spectroscopy (IR) to liquid chromatography (LC) has been applied to study chemical changes in poly(bisphenol A)carbonate (PC) as a result of degradation. Especially coupling of LC to FTIR through solvent elimination is a sensitive approach to identify changes in functionality observed in the LC chromatograms as has been demonstrated by coupling of liquid chromatography under critical conditions (LCCC) to IR. Furthermore, an example is shown in which two-dimensional liquid chromatography, i.e. LCCC × SEC, was coupled to IR by means of a flow cell. This resulted in data sets containing most probably valuable data, but extracting relevant information from these large data sets is not straightforward at all. Therefore, multivariate data analysis (MVDA) of SEC-FTIR data was used to extract relevant data from large data sets. This approach revealed chemical differences due to degradation that could not be detected by other means. Spectral features could be identified that allowed to quantitatively predict the degradation of poly(bisphenol A)carbonate as a function of degradation conditions. © 2006 Elsevier B.V. All rights reserved. Subject BiologyAnalytical researchDegradationInfrared spectroscopyLCCCLiquid chromatographyMultivariate data analysisPoly(bisphenol A)carbonateSECTwo-dimensional liquid chromatographyLCCCMultivariate data analysisPoly(bisphenol A)carbonateSECTwo-dimensional liquid chromatographyData reductionDegradationFourier transform infrared spectroscopyInfrared spectroscopyLiquid chromatographyPhenolsPolycarbonates4,4' isopropylidenediphenolcarbonic acidpoly(bisphenol A)carbonatepolymerunclassified drugarticledegradation kineticsinfrared spectrophotometryinfrared spectroscopyliquid chromatographymultivariate analysispriority journalseparation techniqueChromatography, LiquidMultivariate AnalysisPolymersSpectrophotometry, Infrared To reference this document use: http://resolver.tudelft.nl/uuid:0b36c99f-064f-44c9-852a-bf94d42e6d9f DOI https://doi.org/10.1016/j.chroma.2006.04.070 TNO identifier 239542 ISSN 0021-9673 Source Journal of Chromatography A, 1130 (1 SPEC. ISS.), 34-42 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.