Print Email Facebook Twitter Parenteral Pethidine for labour pain relief and substance use disorder: 20-Year follow-up cohort study in offspring Title Parenteral Pethidine for labour pain relief and substance use disorder: 20-Year follow-up cohort study in offspring Author Pereira, R.R. Kanhai, H. Rosendaal, F. van Dommelen, P. Swaab, D. Pereira, E.R. van de Wetering, B. Publication year 2012 Abstract Objective: To determine whether use of intrapartum Pethidine pain analgesia increases the risk for substance use disorder in adult offspring. Design: Analysis of data from a cohort study. Setting: Academic hospital in Leiden, the Netherlands. Participants: 133 cases and 164 control individuals, aged 18-20 years at follow-up. Main outcome measure: Incidence of substance use disorder or use of alcohol and tobacco. Results: The lifetime use of addictive substances in children exposed to intrapartum Pethidine analgesia was 45% of 133 children versus 48% of 164 not-exposed subjects (adjusted OR=0.79, 95% CI 0.48 to 1.29). Recent use of alcohol, tobacco and hard drugs showed no statistical difference either. Conclusion: Pethidine for labour pain medication appears not to be associated with substance misuse or smoking in later life. Subject HumanCH - Child Health LS - Life StyleBSS - Behavioural and Societal SciencesHealthy for LifeHealthHealthy Living To reference this document use: http://resolver.tudelft.nl/uuid:0aef3e69-b5a1-46db-bb6d-6f2763deef18 DOI https://doi.org/10.1136/bmjopen-2011-000719 TNO identifier 461056 ISSN 2044-6055 Source BMJ Open, 2 (3) Article number No.: e000719 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.