Title
Activation of toll-like receptors and dendritic cells by a broad range of bacterial molecules
Author
Boele, L.C.L.
Bajramovic, J.J.
de Vries, A.M.M.B.C.
Voskamp-Visser, I.A.I.
Kaman, W.E.
van der Kleij, D.
TNO Defensie en Veiligheid
Publication year
2009
Abstract
Activation of pattern recognition receptors such as Toll-like receptors (TLRs) by pathogens leads to activation and maturation of dendritic cells (DC), which orchestrate the development of the adaptive immune response. To create an overview of the effects of a broad range of pathogenic bacteria, their capacity to activate TLRs and to affect DC maturation, cytokine production and T cell polarizing capacity were determined. Different bacterial species differed in their potency to affect these parameters. In general, on the DC level differences were found in the maturation-inducing capacity of gram-negative and gram-positive bacteria. Remarkably, these differences did not result in differential polarization of the T cell response. With respect to TLRs, TLR4 activation by pathogens correlated with their ability to induce DC maturation, while for TLR2 and TLR5 such a correlation was absent. Taken together, this study provides insight into qualitative differences and general effects of pathogen-derived molecules on dendritic cells. © 2008 Elsevier Inc. All rights reserved. Chemicals / CAS: toll like receptor 2, 203811-81-8; toll like receptor 4, 203811-83-0; toll like receptor, 409141-78-2; Antigens, CD; Biological Markers; Cytokines; HLA-DR Antigens; Ligands; Protein Isoforms; Toll-Like Receptors
Subject
Biology
Bacteria
Cytokines
Dendritic cell
Pathogens
Toll-like receptor
toll like receptor
toll like receptor 2
toll like receptor 4
toll like receptor 5
article
cell maturation
cell polarity
controlled study
cytokine production
dendritic cell
genetic transfection
human
human cell
priority journal
Staphylococcus aureus
T lymphocyte
Vibrio cholerae
Yersinia pestis
Yersinia pseudotuberculosis
Animals
Antigens, CD
Bacteria
Biological Markers
Cell Line
Coculture Techniques
Cytokines
Dendritic Cells
HLA-DR Antigens
Humans
Ligands
Protein Isoforms
T-Lymphocytes
Toll-Like Receptors
Ultraviolet Rays
Bacteria (microorganisms)
Negibacteria
Posibacteria
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DOI
https://doi.org/10.1016/j.cellimm.2008.09.002
TNO identifier
27880
Source
Cellular Immunology, 255 (1-2), 17-25
Document type
article