Title
Effect of fumonisin B1 on rat hepatic P450 system
Author
Spotti, M.
Maas, R.F.M.
de Nijs, C.M.
Fink-Gremmels, J.
Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2000
Abstract
The effects of the mycotoxin fumonisin B1 (FB1) on the hepatic cytochrome P450 system were investigated in male rats dosed daily by oral gavage with 3 mg FB1 per kg body weight for 9 consecutive days. FB1 treatment resulted in a reduced weight gain. At the same time, CYP2E activity was increased, which is considered to mark the metabolic changes inherent to growth retardation in young rats. Treatment with FB1 also resulted in a selective inhibition of CYP2C11 and to a lesser extent, CYP1A2 in liver microsomes obtained from treated animals, whereas it did not affect significantly the activity of CYP2A1/2A2, CYP2B1/2B2, CYP3A1/3A2 and CYP4A. The significant inhibition of CYP2C11 is considered to reflect a suppressed activity of protein kinase activity resulting from the inhibition of sphingolipid biosynthesis caused by FB1. Copyright (C) 2000 Elsevier Science B.V. Chemicals/CAS: cytochrome P450 3A, 329322-82-9; cytochrome P450, 9035-51-2; dimethylnitrosamine demethylase, 9075-31-4; fumonisin B1, 116355-83-0; pentoxyresorufin dealkylase, 96595-04-9; phenacetin o deethylase, 67724-61-2; protein kinase, 9026-43-1
Subject
Nutrition
Cytochrome P450
Fumonisin B1
Liver
Rat
Cytochrome P450 3A
Dimethylnitrosamine demethylase
Fumonisin B1
Isoenzyme
Pentoxyresorufin dealkylase
Phenacetin o deethylase
Protein kinase
Sphingolipid
Animal model
Body weight
Controlled study
Enzyme activity
Growth retardation
Male
Metabolism
Nonhuman
Oral drug administration
Priority journal
Rat
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DOI
https://doi.org/10.1016/s1382-6689(00)00040-5
TNO identifier
87232
ISSN
1382-6689
Source
Environmental Toxicology and Pharmacology, 8 (3), 197-204
Document type
article