Title
LDL oxidation and extent of coronary atherosclerosis
Author
van de Vijver, L.P.L.
Kardinaal, A.F.M.
van Duyvenvoorde, W.
Kruijssen, D.A.C.M.
Grobbee, D.E.
van Poppel, G.
Princen, H.M.G.
TNO Preventie en Gezondheid
Publication year
1998
Abstract
Accumulated evidence indicates that oxidative modification of LDL plays an important role in the atherogenic process. Therefore, we investigated the relation between coronary atherosclerosis and susceptibility of LDL to oxidation in a case-control study in men between 45 and 80 years of age. Case subjects and hospital control subjects were selected from subjects undergoing a first coronary angiography. Subjects with severe coronary stenosis (≤85% stenosis in one and ≤50% stenosis in a second major coronary vessel) were classified as case subjects (n=91). Hospital control subjects with no or minor stenosis (≤50% stenosis in no more than two of the three major coronary vessels, n=94) and population control subjects flee of plaques in the carotid artery (n=85) were pooled for the statistical analysis into one control category. Enrollment procedures allowed for similar distributions in age and smoking habits. Case subjects had higher levels of total and LDL cholesterol and triglycerides and lower levels of HDL cholesterol. Resistance time, maximum rate of oxidation, and maximum diene production were measured ex vivo using copper-induced LDL oxidation. A borderline significant inverse trend was observed for coronary atherosclerosis risk at increasing resistance time. Odds ratios (95% confidence interval) for the successive quartiles were 1.0 (reference), 0.77 (0.39 to 1.53), 0.67 (0.33 to 1.34), and 0.55 (0.27 to 1.15) (P(trend)=0.07). No relation with maximum rate of oxidation was found, and higher maximum diene levels were found in control subjects (P<.01). The main determinant of oxidation was the fatty acid composition of LDL. No effect of smoking or use of medication was observed. We conclude that although LDL resistance to oxidation may be a factor in atherogenesis, the ex vivo measure is not a strong predictor of severity of coronary atherosclerosis.
Subject
Biology
Atherosclerosis
LDL composition
LDL oxidation
Propagation rate
Resistance time
High density lipoprotein cholesterol
Low density lipoprotein
Low density lipoprotein cholesterol
Triacylglycerol
Adult
Aged
Artery resistance
Controlled study
Coronary artery atherosclerosis
Coronary artery obstruction
Coronary risk
Disease severity
Human
Lipid composition
Lipid oxidation
Major clinical study
Male
Priority journal
Aged
Aged, 80 and over
Coronary Angiography
Coronary Arteriosclerosis
Female
Humans
Lipoproteins
Male
Middle Aged
Odds Ratio
Oxidation-Reduction
Predictive Value of Tests
Risk Factors
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TNO identifier
234514
ISSN
1079-5642
Source
Arteriosclerosis, Thrombosis, and Vascular Biology, 18 (2), 193-199
Document type
article