Print Email Facebook Twitter Effects of long term feeding of raw soya bean flour on virus- induced pancreatic carcinogenesis in guinea fowl Title Effects of long term feeding of raw soya bean flour on virus- induced pancreatic carcinogenesis in guinea fowl Author Kirev, T. Woutersen, R.A. Kiril, A. Centraal Instituut voor Voedingsonderzoek TNO Publication year 1999 Abstract The effects of a diet enriched with 25% raw soya bean flour (RSF) on the pancreas and on the avian retrovirus Pts 56-induced pancreatic carcinogenesis in guinea fowl were studied. It has been shown that prolonged RSF feeding of new-hatched virus-infected and uninfected guinea fowl-poults induced enlargement of the pancreas, which was less pronounced when administration of the RSF supplemented diet started at the age of 75 days. Time-dependent multifocal inter- and intralobular hyperplasia of pleomorphic ducts lined by mucin-producing epithelium in the exocrine pancreas of virus-infected guinea fowls fed a RSF supplemented diet was regularly observed. Enlargement of virus-induced ductular neoplasms has been shown only after simultaneous RSF and virus administration. Copyright (C) 1999 Elsevier Science Ireland Ltd. Subject NutritionGuinea fowlPancreatic carcinogenesisRaw soya bean flourBirdCarcinogenesisDietHistologyMicroscopyPancreas cancerPriority journalRetrovirusSoybeanVirus infectionAnimalsAnimals, NewbornBody WeightCarcinogenicity TestsCocarcinogenesisFemaleFlourHyperplasiaMalePancreasPancreatic DuctsPancreatic NeoplasmsPoultryRandom AllocationRetroviridaeRetroviridae InfectionsSoybeansTumor Virus Infections To reference this document use: http://resolver.tudelft.nl/uuid:08e58e01-2a3e-4574-91d7-cdddb86cd80e DOI https://doi.org/10.1016/s0304-3835(98)00296-1 TNO identifier 234924 ISSN 0304-3835 Source Cancer Letters, 135 (2), 195-202 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.