Title
A category approach to predicting the developmental (neuro) toxicity of organotin compounds: The value of the zebrafish (Danio rerio) embryotoxicity test (ZET)
Author
Beker van Woudenberg, A.
Wolterbeek, A.
te Brake, L.
Snel, C.
Menke, A.
Rubingh, C.
de Groot, D.
Kroese, D.
Publication year
2013
Abstract
Zebrafish embryos were exposed to different organotin compounds during very early development (<100. h post fertilization). Morphology, histopathology and swimming activity (in a motor activity test) were the endpoints analyzed. DBTC was, by far, the most embryotoxic compound at all time points and endpoints studied. In fact, we observed a clear concordance between the effects observed in our zebrafish embryo model, and those observed with these compounds in full rodent in vivo studies. All organotin compounds classified as developmental (neuro) toxicants in vivo, were correctly classified in the present assay. Together, our results support the ZET model as a valuable tool for providing biological verification for a grouping and a read-across approach to developmental (neuro) toxicity. © 2013 Elsevier Inc.
Subject
Life Triskelion BV
QS - Quality & Safety TARA - Toxicology and Risk Assessment
EELS - Earth, Environmental and Life Sciences
Biomedical Innovation
Health
Healthy Living
Alternative model
Biological verification
Developmental (neuro) toxicity
Grouping
Organotins
Read across
Zebrafish embryotoxicity test (ZET)
To reference this document use:
http://resolver.tudelft.nl/uuid:07f5b91d-0c39-4e88-93b5-41e8f235223a
DOI
https://doi.org/10.1016/j.reprotox.2013.06.067
TNO identifier
478864
ISSN
0890-6238
Source
Reproductive Toxicology, 41, 35-44
Document type
article