Print Email Facebook Twitter General aspects of immunotoxicology including validation issues Title General aspects of immunotoxicology including validation issues Author Frieke Kuper, C. TNO Kwaliteit van Leven Publication year 2006 Abstract Histologic examination of lymphoid organs has revealed immunotoxic effects of a broad range of substances. The thymus has proven especially sensitive. The relative lack of sensitivity of mucosa-associated lymphoid cells and tissues may be due to shortcomings in the way they are examined. Validation of ways to examine mucosal lymphoid tissues and cells and development of histopathological tools to flag a compound as a potential inducer of autoimmune disease or allergy are challenges for the future. © 2006 Elsevier GmbH. All rights reserved. Subject BiologyToxicology and Applied PharmacologyImmunopathologyOrgan samplingValidationallergyarticleautoimmune diseasehistologyhistopathologyhumanimmunotoxicityimmunotoxicologylymphoid celllymphoid organlymphoid tissuesensitivity and specificitythymustoxicologyvalidation studyAnimalsImmune SystemImmunosuppressive AgentsLymphoid TissueReproducibility of ResultsToxicity TestsXenobiotics To reference this document use: http://resolver.tudelft.nl/uuid:07b309ea-0da6-4715-b2f3-00bc27a0cd9d DOI https://doi.org/10.1016/j.etp.2006.03.007 TNO identifier 239364 ISSN 0940-2993 Source Experimental and Toxicologic Pathology, 57 (5-6), 363-366 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.