Print Email Facebook Twitter Selective association of multiple sclerosis with infectious mononucleosis Title Selective association of multiple sclerosis with infectious mononucleosis Author Zaadstra, B.M. Chorus, A.M.J. van Buuren, S. Kalsbeek, H. van Noort, J.M. TNO Defensie en Veiligheid TNO Kwaliteit van Leven DenV KvL Publication year 2008 Abstract Previous studies have suggested an association between multiple sclerosis (MS) and infectious mononucleosis (IM) but data on the exact strength of this association or its selectivity have been conflicting. In this study we have evaluated the association between MS and a variety of common childhood infections and afflictions in a large population-based case-control study involving 2877 MS cases and 2673 controls in the Netherlands. We examined the frequency of different common infections and afflictions before the age of 25 and the age at which they occurred, using a self-administered questionnaire. The Odds ratios (ORs) for the occurrence of a variety of clinically manifest common childhood infections including rubella, measles, chicken pox and mumps before the age of 25 for MS cases versus controls ranged between 1.14 and 1.42, values similar to those for irrelevant probe variables used to reveal recall bias. In contrast, the OR for clinically manifest IM in MS cases versus controls, corrected for demographic variables, was 2.22 (95% confidence interval 1.73-2.86; P < 0.001). The average age of onset of IM in the population of MS cases (16.5 years) did not differ from controls (16.8 years). Our data confirm previous much smaller studies to show that the risk for MS is significantly enhanced by prior IM, and extend those previous data by showing that this association is far stronger than with other common childhood infections or afflictions. © 2008 SAGE Publications. Subject HealthBiomedical ResearchImmunologyMultiple sclerosisadolescentadultagedarticlechickenpoxchildhood diseaseclinical featurecomorbiditycontrolled studydemographydisease associationEpstein Barr virusfemalehumaninfectious mononucleosismajor clinical studymalemultiple sclerosismumpsNetherlandsonset agepopulation based case control studyquestionnairerisk assessmentrisk factorrubellavirus infectionAdolescentAdultAge DistributionAgedCase-Control StudiesChickenpoxFemaleHumansInfectious MononucleosisMaleMeaslesMiddle AgedMultiple SclerosisMumpsPrevalenceRisk FactorsRubella To reference this document use: http://resolver.tudelft.nl/uuid:06a9dae9-1bfc-49eb-b367-d53fad5472f0 DOI https://doi.org/10.1177/1352458507084265 TNO identifier 240723 ISSN 1352-4585 Source Multiple Sclerosis, 14 (3), 307-313 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.