Title
Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritation
Author
Vandebriel, R.
Callant Cransveld, C.
Crommelin, D.
Diamant, Z.
Glazenburg, B.
Joos, G.
Kuper, F.
Natsch, A.
Nijkamp, F.
Noteborn, H.
Pieters, R.
Roberts, D.
Roggen, E.
Rorije, E.
Seed, M.
Sewald, K.
van den Heuvel, R.
van Engelen, J.
Verstraelen, S.
van Loveren, H.
Publication year
2011
Abstract
Respiratory sensitization provides a case study for a new approach to chemical safety evaluation, as the prevalence of respiratory sensitization has increased considerably over the last decades, but animal and/or human experimental/predictive models are not currently available. Therefore, the goal of a working group was to design a road map to develop an ASAT approach for respiratory sensitisers. This approach should aim at (i) creating a database on respiratory functional biology and toxicology, (ii) applying data analyses to understand the multi-dimensional sensitization response, and how this predisposes to respiratory inflammation and irritation, and (iii) building a systems model out of these analyses, adding pharmacokinetic-pharmacodynamic modeling to predict respiratory responses to low levels of sensitisers. To this end, the best way forward would be to follow an integrated testing approach. Experimental research should be targeted to (i) QSAR-type approaches to relate potential as a respiratory sensitizer to its chemical structure, (ii) in vitro models and (iii) in vitro-in vivo extrapolation/validation. © 2011 Elsevier Ltd.
Subject
Life
QS - Quality & Safety
EELS - Earth, Environmental and Life Sciences
Healthy for Life
Toxicology
Healthy Living
ASAT
Asthma
In vitro
In vivo
Integrated testing
QSAR
Respiratory tract
Rhinitis
Risk assessment
Sensitization
contact allergen
immunoglobulin E
airway remodeling
animal testing alternative
biosafety
bronchus hyperreactivity
cell assay
cellular immunity
dendritic cell
disease predisposition
functional genomics
human
immunopathology
immunoreactivity
in vitro study
mathematical model
mucosal immunity
nonhuman
occupational asthma
predictive value
process development
process model
quantitative analysis
quantitative structure activity relation
reaction analysis
respiratory sensitization
respiratory tract inflammation
respiratory tract injury
review
risk assessment
risk factor
sensitization
Animal Testing Alternatives
Hazardous Substances
Humans
Respiratory Hypersensitivity
Respiratory Tract Diseases
Toxicity Tests
Animalia
To reference this document use:
http://resolver.tudelft.nl/uuid:06a93dff-323e-4cb3-bc10-a7e989c0982d
DOI
https://doi.org/10.1016/j.tiv.2011.04.027
TNO identifier
460484
ISSN
0887-2333
Source
Toxicology in Vitro, 25 (7), 1251-1258
Document type
article