Print Email Facebook Twitter Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes Title Dietary fat and risk of colon and rectal cancer with aberrant MLH1 expression, APC or KRAS genes Author Weijenberg, M.P. Lüchtenborg, M. de Goeij, A.F.P.M. Brink, M. van Muijen, G.N.P. de Bruïne, A.P. Goldbohm, R.A. van den Brandt, P.A. TNO Kwaliteit van Leven Publication year 2007 Abstract Objective: To investigate baseline fat intake and the risk of colon and rectal tumors lacking MLH1 (mutL homolog 1, colon cancer, nonpolyposis type 2) repair gene expression and harboring mutations in the APC (adenomatous polyposis coli) tumor suppressor gene and in the KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog) oncogene. Methods: After 7.3 years of follow-up of the Netherlands Cohort Study (n = 120,852), adjusted incidence rate ratios (RR) and 95% confidence intervals (CI) were computed, based on 401 colon and 130 rectal cancer patients. Results: Total, saturated and monounsaturated fat were not associated with the risk of colon or rectal cancer, or different molecular subgroups. There was also no association between polyunsaturated fat and the risk of overall or subgroups of rectal cancer. Linoleic acid, the most abundant polyunsaturated fatty acid in the diet, was associated with increased risk of colon tumors with only a KRAS mutation and no additional truncating APC mutation or lack of MLH1 expression (RR = 1.41, 95% CI 1.18-1.69 for one standard deviation (i.e., 7.5 g/day) increase in intake, p-trend over the quartiles of intake <0.001). Linoleic acid intake was not associated with risk of colon tumors without any of the gene defects, or with tumors harboring aberrations in either MLH1 or APC. Conclusion: Linoleic acid intake is associated with colon tumors with an aberrant KRAS gene, but an intact APC gene and MLH1 expression, suggesting a unique etiology of tumors with specific genetic aberrations. © 2007 Springer Science + Business Media B.V. Subject HealthFood and Chemical Risk AnalysisColorectal NeoplasmsDietary FatsEpidemiologyMolecularAPC proteinK ras proteinlinoleic acidmonounsaturated fatty acidpolyunsaturated fatty acidprotein MLH1saturated fatty acidadultcancer epidemiologycancer incidencecancer riskchromosome aberrationcohort analysiscolon cancerconfidence intervalcontrolled studyfat intakegene expressiongene mutationgenetic disorderhuman tissuemajor clinical studyoncogenepriority journalprotein expressionrectum cancerrisk assessmenttumor suppressor geneAdaptor Proteins, Signal TransducingAdenomatous Polyposis Coli ProteinAgedCohort StudiesColorectal NeoplasmsDietDietary FatsFemaleFollow-Up StudiesGenes, rasHumansImmunoenzyme TechniquesMaleMiddle AgedMutationNetherlandsNuclear ProteinsProspective Studies To reference this document use: http://resolver.tudelft.nl/uuid:062159ce-b8b3-4a3e-96f1-d61a794d903c DOI https://doi.org/10.1007/s10552-007-9032-6 TNO identifier 240205 ISSN 0957-5243 Source Cancer Causes and Control, 18 (8), 865-879 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.