Title
In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?
Author
Havenaar, R.
Anneveld, B.
Hanff, L.M.
de Wildt, S.N.
de Koning, B.A.E.
Mooij, M.G.
Lelieveld, J.P.A.
Minekus, M.
Publication year
2013
Abstract
There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the conditions in the upper gastrointestinal tract of neonates, infants and toddlers: TIMpediatric. Paracetamol and diclofenac in age-related food matrices and with esomeprazole co-medication were tested. The experiments showed relevant results on the impact of drug manipulation and co-medication on the availability for absorption of active compounds. Without ethical constraints, alternative approaches for oral dosing and new pediatric formulations can be studied in TIMpediatric with a high predictive value. © 2013 Elsevier B.V.
Subject
Life
PHS - Pharmacokinetics & Human Studies (tot 2013 daarna KFP)
EELS - Earth, Environmental and Life Sciences
Biomedical Innovation
Biology
Healthy Living
Bioaccessibility
Drug handling
In vitro gastrointestinal model
Pediatric drug
To reference this document use:
http://resolver.tudelft.nl/uuid:05bb31ad-c144-4c2e-85c7-e4423498a083
DOI
https://doi.org/10.1016/j.ijpharm.2013.07.053
TNO identifier
484270
ISSN
0378-5173
Source
International Journal of Pharmaceutics, 457 (1), 327-332
Document type
article