In vitro gastrointestinal model (TIM) with predictive power, even for infants and children?
de Wildt, S.N.
de Koning, B.A.E.
There is a need for information on the bioavailability in pediatric patients of drugs from manipulated dosage forms when applied in combination with food and/or co-medication under realistic daily practice circumstances. We describe the development, validation and application of a dynamic, computer-controlled in vitro system mimicking the conditions in the upper gastrointestinal tract of neonates, infants and toddlers: TIMpediatric. Paracetamol and diclofenac in age-related food matrices and with esomeprazole co-medication were tested. The experiments showed relevant results on the impact of drug manipulation and co-medication on the availability for absorption of active compounds. Without ethical constraints, alternative approaches for oral dosing and new pediatric formulations can be studied in TIMpediatric with a high predictive value. © 2013 Elsevier B.V.
To reference this document use:
PHS - Pharmacokinetics & Human Studies (tot 2013 daarna KFP)
EELS - Earth, Environmental and Life Sciences
In vitro gastrointestinal model
International Journal of Pharmaceutics, 457 (1), 327-332