Print Email Facebook Twitter Sodium intake and blood pressure in renal transplant recipients Title Sodium intake and blood pressure in renal transplant recipients Author van den Berg, E. Geleijnse, J.M. Brink, E.J. van Baak, M.A. Homan van der Heide, J.J. Gans, R.O.B. Navis, G. Bakker, S.J.L. Publication year 2012 Abstract Background. Hypertension is common among renal transplant recipients (RTR) and a risk factor for graft failure and mortality. Sodium intake is a well-established determinant of blood pressure (BP) in the general population. However, data in RTR are limited. International guidelines recommend a maximum daily sodium intake of 70 mmol. We investigated sodium intake in RTR as compared to healthy controls and its association with BP. Methods. We included 660 RTR (age 53 ± 13 years, 58 male) and 201 healthy controls (age 54 ± 11 years, 46 male). Sodium intake was assessed from 24-h urine collections. The morning after completion of urine collection, BP was measured according to a strict protocol. Results. Urinary sodium excretion was 156 ± 62 mmol/24 h in RTR and 195 ± 75 in controls (difference: P < 0.001), and 95 of RTR had a urinary sodium excretion >70 mmol/24 h. Systolic BP (SBP) and diastolic BP (DBP) were 136 ± 18 and 82 ± 11 mmHg, respectively. Sodium intake was positively associated with SBP (β 0.042 mmHg/mmol/24 h, P 0.002) and DBP (β 0.023 mmHg/mmol/24 h, P 0.007), independent of potential confounders. Conclusion. sAlthough RTR had a lower sodium intake than healthy controls, their intake still exceeded current guidelines. Reduction of sodium intake to recommended amounts could reduce SBP by 45 mmHg. Better control of sodium intake may help to prevent graft failure and mortality due to hypertension among RTR. © The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. Subject LifePHS - Pharmacokinetics & Human StudiesEELS - Earth, Environmental and Life SciencesHealthy for LifeHealthHealthy Livingblood pressurerenal transplantationsodium intake To reference this document use: http://resolver.tudelft.nl/uuid:05a9e900-524b-48c8-8668-94d16e784f6c DOI https://doi.org/10.1093/ndt/gfs069 TNO identifier 462873 ISSN 0931-0509 Source Nephrology Dialysis Transplantation, 27 (8), 3352-3359 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.