Print Email Facebook Twitter Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study Title Vegetables and fruits consumption and risk of esophageal and gastric cancer subtypes in the Netherlands Cohort Study Author Steevens, J. Schouten, L.J. Goldbohm, R.A. van den Brandt, P.A. Publication year 2011 Abstract Prospective epidemiologic data on vegetables and fruits consumption and risk of subtypes of esophageal and gastric cancer are sparse. We studied the association between vegetables and fruits consumption and risk of esophageal squamous cell carcinoma (ESCC), esophageal adenocarcinoma (EAC), gastric cardia adenocarcinoma (GCA) and gastric noncardia adenocarcinoma (GNCA) in the Netherlands Cohort Study. In 1986, 120,852 Dutch men and women aged 55-69 filled out a questionnaire on diet and other cancer risk factors. After 16.3 years of follow-up, 101 ESCC, 144 EAC, 156 GCA, 460 GNCA cases and 4,035 subcohort members were available for case-cohort analysis using Cox proportional hazards models. Multivariable adjusted incidence rate ratios (RRs) were generally below unity. Total vegetable consumption was nonsignificantly inversely associated with EAC and ESCC risk, but not with GCA and GNCA risk. Significant inverse associations were observed for raw vegetables and EAC risk [RR per 25 g/day: 0.81, 95% confidence interval (CI) 0.68-0.98], and Brassica vegetables and GCA risk (RR per 25 g/day: 0.72, 95% CI 0.54-0.95). Total fruit consumption was associated with a nonsignificantly decreased EAC risk. Citrus fruits were inversely associated with EAC and GCA risk (RRs for highest vs. lowest intake: 0.55, 95% CI 0.31-0.98 and 0.38, 95% CI 0.21-0.69, respectively). Specifically for current smokers, vegetables and possibly also fruits intake was inversely associated with ESCC and EAC risk. Consumption of (specific groups of) vegetables and fruits may protect against subtypes of esophageal and gastric cancer. Copyright © 2011 UICC. Subject HealthEpidemiologyEsophageal cancerStomach cancerAdultAgedBrassicaCancer incidenceCancer riskCardia carcinomaCigarette smokingCitrus fruitCohort analysisControlled studyEsophageal adenocarcinomaEsophageal squamous cell carcinomaFeeding behaviorFollow upFood intakeFruitMajor clinical studyNetherlandsProportional hazards modelQuestionnaireRisk factorRisk reductionStomach adenocarcinomaAdenocarcinomaAgedCarcinoma, Squamous CellCardiaCohort StudiesEsophageal NeoplasmsFemaleFollow-Up StudiesFruitHumansMaleMiddle AgedPrognosisProspective StudiesRisk FactorsStomach NeoplasmsSurvival RateVegetables To reference this document use: http://resolver.tudelft.nl/uuid:017802b1-9f69-4545-b9ae-7db37ca39ede DOI https://doi.org/10.1002/ijc.25928 TNO identifier 526412 ISSN 0020-7136 Source International Journal of Cancer, 129 (11), 2681-2693 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.