Print Email Facebook Twitter A guide to murine coagulation factor structure, function, assays, and genetic alterations Title A guide to murine coagulation factor structure, function, assays, and genetic alterations Author Emeis, J.J. Jirouskova, M. Muchitsch, E.-M. Shet, A.S. Smyth, S.S. Johnson, G.J. TNO Preventie en Gezondheid Publication year 2007 Abstract Murine blood coagulation factors and function are quite similar to those of humans. Because of this similarity and the adaptability of mice to genetic manipulation, murine coagulation factors and inhibitors have been extensively studied. These studies have provided significant insights into human hemostasis. They have also provided useful experimental models for evaluation of the pathophysiology and treatment of thrombosis. This review contains recommendations for obtaining, processing and assaying mouse blood hemostatic components, and it summarizes the extensive literature on murine coagulation factor structure and function, assays and genetic alteration. It is intended to be a convenient reference source for investigators of hemostasis and thrombosis. © 2007 International Society on Thrombosis and Haemostasis. Chemicals / CAS: antithrombin, 9000-94-6; blood clotting factor 10, 9001-29-0; blood clotting factor 13, 9013-56-3; blood clotting factor 5, 9001-24-5, 9013-23-4; blood clotting factor 7, 9001-25-6; blood clotting factor 8, 9001-27-8; blood clotting factor 9, 9001-28-9; fibrinogen, 9001-32-5; heparin cofactor II, 81604-65-1; protein C, 60202-16-6; prothrombin, 9001-26-7; thrombin, 9002-04-4; thrombomodulin, 112049-68-0; tissue factor pathway inhibitor, 116638-34-7; von Willebrand factor, 109319-16-6; Fibrinogen, 9001-32-5 Subject AudiologyAntithrombinBlood clotting factorBlood clotting factor 10Blood clotting factor 13Blood clotting factor 5Blood clotting factor 7Blood clotting factor 8Blood clotting factor 9D dimerEndothelial protein C receptorFibrinogenHeparin cofactor IIProtein CProtein SThrombinThrombomodulinTissue factor pathway inhibitorVon Willebrand factorAtherosclerosisEnzyme linked immunosorbent assayGene mutationImmunoelectrophoresisMetastasisNonhumanPartial thromboplastin timePhenotypeProtein functionProtein structureThrombocyte aggregationTumor vascularizationWestern blottingWound healingAnimalsBlood CoagulationDisease Models, AnimalFibrinogenHemostasisHumansMiceModels, BiologicalModels, GeneticPartial Thromboplastin TimeProthrombin TimeThrombosis To reference this document use: http://resolver.tudelft.nl/uuid:0171354a-96e4-4f6c-8e32-1e698da69c62 DOI https://doi.org/10.1111/j.1538-7836.2007.02408.x TNO identifier 239925 ISSN 1538-7933 Source Journal of Thrombosis and Haemostasis, 5 (4), 670-679 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.