Title
The effect of age on the biliary excretion of digitoxin and its metabolites in female BN/Bi rats
Author
Instituut voor experimentele gerontologie TNO
Kitani, K.
Sato, Y.
van Bezooijen, K.
Publication year
1982
Abstract
The biliary excretion of digitoxin (Dt3) and its metabolites was studied in female BN/Bi rats of different ages ranging from 3 to 30 mth. The disappearance of radioactivity from plasma after an i.v. injection of [3H]Dt3 (0.01 mg/100 g body weight) gradually slowed as rat age advanced. The 2-h biliary recovery of radioactivity (percent of the dose) also showed an age-dependent decrease resulting in a 43% decrease at 30 mth compared to the 3-mth-old value. The amount of unchanged Dt3 in the bile, which was about 20% of the total activity in the bile of 3-mth-old rats, did not decrease with age, while the excretion of various Dt3 metabolites all decreased with age. It is suggested that the capacity of the liver to metabolize Dt3 is decreased with age in female BN/Bi rats, which may cause an alteration in the Dt3 pharmacokinetics with age. Chemicals/CAS: digitoxin, 71-63-6; Digitoxigenin, 143-62-4; Digitoxin, 71-63-6; Digoxigenin, 1672-46-4
Subject
digitoxin
radioisotope
age
animal experiment
bile flow
digitoxin h 3
drug bile level
drug clearance
drug elimination
drug metabolism
intravenous drug administration
liver
liver function
metabolism
nonhuman
pharmacokinetics
rat
Aging
Animal
Bile
Digitoxigenin
Digitoxin
Digoxigenin
Female
Rats
Rats, Inbred BN
Support, Non-U.S. Gov't
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DOI
https://doi.org/10.1016/0167-4943(82)90005-x
TNO identifier
229318
ISSN
0167-4943
Source
Archives of Gerontology and Geriatrics, 1 (1), 43-54
Document type
article