Title
Beat-to-beat noninvasive stroke volume from arterial pressure and Doppler ultrasound
Author
van Lieshout, J.J.
Toska, K.
van Lieshout, E.J.
Eriksen, M.
Walløe, L.
Wesseling, K.H.
TNO Biomedical Instrumentation
Publication year
2003
Abstract
The proper understanding of the cardiovascular mechanisms involved in complaints of short-lasting dizziness and the evaluation of unexplained recurrent syncope requires continuous monitoring of cardiac stroke volume (SV) in addition to blood pressure and heart rate. The primary aim of the present study was to evaluate a pulse wave analysis method that calculates beat-to-beat flow from non-invasive arterial pressure by simulating a non-linear, time-varying model of human aortic input impedance (Modelflow; MF), by comparing MF stroke volume (SVMF) to Doppler ultrasound (US) flow velocity SV (SVUS). A second purpose was to compare the two methods under two different conditions: the supine and head-up tilt (30°) position. SVUS and SVMF with non-invasive arterial pressure (Finapres) as input to the aortic model were measured beat-to-beat during spontaneous supine breathing and in the passive 30° head-up tilt (HUT30) position in six normotensive healthy humans [three females, mean age 24 (21-26) years]. There were variations in supine SV track between the two methods with zero difference and a SD of the beat-to-beat difference (MF-US) of 4.2%. HUT30 induced a systematic difference of 10.5% and an increase in SD to 6.9%, which was reproducible. Beat-to-beat changes in SV in the supine resting condition were equally well assessed by both methods. Systematic differences appear during HUT30 and show opposite signs. The difference between the two methods upon a change in body position may be attributed to limitations in each method.
Subject
Arrhythmia
Computer modeling
Syncope
analytic method
arterial pressure
body position
breathing pattern
calculation
controlled study
Doppler echography
flow rate
head tilting
heart beat
heart stroke volume
human experiment
impedance
intermethod comparison
medical instrumentation
non invasive measurement
nonbiological model
nonlinear system
normal human
priority journal
pulse wave
reproducibility
rest
simulation
standard
supine position
Adult
Aorta
Blood Pressure
Computer Simulation
Diagnosis, Computer-Assisted
Female
Heart Rate
Humans
Male
Models, Cardiovascular
Posture
Pulsatile Flow
Reproducibility of Results
Sensitivity and Specificity
Stroke Volume
Supine Position
Ultrasonography, Doppler
To reference this document use:
http://resolver.tudelft.nl/uuid:009aee2b-d908-4ec2-a989-d0c2a762d9ce
DOI
https://doi.org/10.1007/s00421-003-0901-8
TNO identifier
237245
ISSN
1439-6319
Source
European Journal of Applied Physiology, 90 (1-2), 131-137
Document type
article