Title
Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women
Author
Schuit, A.J.
Schouten, E.G.
Kluft, C.
de Maat, M.
Menheere, P.P.C.A.
Kok, F.J.
Gaubius Instituut TNO
Publication year
1997
Abstract
The elevated incidence of thrombotic disease in elderly people may be associated with an increase in PAI-1 and fibrinogen with ageing. Cross-sectional studies report an inverse relation of PAI-1 and fibrinogen with physical activity, but training studies show inconsistent results. In a controlled intervention study among elderly subjects (aged 60-80 years) we observed a moderate decrease in PAI-1 antigen (4%, -2.1 ± 2.4 ng/ml), a significant increase in t-PA activity (11%, 0.07 ± 0.04 IU/ml) and an unexpected significant increase in fibrinogen (6%, 0.18 ± 0.07 g/l) in subjects following a 6-month intensive training program as compared to controls. Reduction in PAI-1 antigen was significantly associated with a decrease in triglycerides (β = 10.3 ng/ml per 1 mM, p < 0.01) and insulin (β = 2.37 ng/ml per 1 mU/l, p = 0.07). Increase in fibrinogen coincided with a rise in C-reactive protein (p < 0.001). These data suggest that regular intensive activity may increase fibrinolytic activity in a moderate way, but also may cause chronically elevated plasma levels of acute phase proteins in elderly persons. Copyright © 1997 Schattauer Verlag
Subject
Biology
acute phase protein
c reactive protein
insulin
plasminogen activator inhibitor 1
tissue plasminogen activator
triacylglycerol
adult
aging
blood level
controlled study
exercise
female
fibrinogen blood level
human experiment
insulin blood level
normal human
thrombosis
training
triacylglycerol blood level
Aged
Aged, 80 and over
Body Weight
Exercise
Female
Fibrinogen
Fibrinolysis
Humans
Male
Middle Aged
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DOI
https://doi.org/10.1055/s-0038-1657639
TNO identifier
233992
ISSN
0340-6245
Source
Thrombosis and Haemostasis, 78 (2), 845-851
Document type
article