Print Email Facebook Twitter A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity Title A mode-of-action ontology model for safety evaluation of chemicals: Outcome of a series of workshops on repeated dose toxicity Author Desprez, B. Birk, B. Blaauboer, B. Boobis, A. Carmichael, P. Cronin, M.T.D. Curie, R. Daston, G. Hubesch, B. Jennings, P. Klaric, M. Kroese, D. Mahony, C. Ouédraogo, G. Piersma, A. Richarz, A.N. Schwarz, M. van Benthem, J. van de Water, B. Vinken, M. Publication year 2019 Abstract Repeated dose toxicity evaluation aims at assessing the occurrence of adverse effects following chronic or repeated exposure to chemicals. Non-animal approaches have gained importance in the last decades because of ethical considerations as well as due to scientific reasons calling for more human-based strategies. A critical aspect of this challenge is linked to the capacity to cover a comprehensive set of interdependent mechanisms of action, link them to adverse effects and interpret their probability to be triggered in the light of the exposure at the (sub)cellular level. Inherent to its structured nature, an ontology addressing repeated dose toxicity could be a scientific and transparent way to achieve this goal. Additionally, repeated dose toxicity evaluation through the use of a harmonized ontology should be performed in a reproducible and consistent manner, while mimicking as accurately as possible human physiology and adaptivity. In this paper, the outcome of a series of workshops organized by Cosmetics Europe on this topic is reported. As such, this manuscript shows how experts set critical elements and ways of establishing a mode-of-action ontology model as a support to risk assessors aiming to perform animal-free safety evaluation of chemicals based on repeated dose toxicity data. © 2019 Subject Adverse outcome pathwayMode-of-actionOntology modelRepeated dose toxicityCosmeticAdverse outcomeBiotransformationChemical parametersChemical structureCytotoxicityExposureHumanKineticsMetabolismMode of actionNonhumanNoteOntologyOrgan distributionPhysical chemistryRepeated dose toxicitySafetyToxicity testingToxicologyWorkflow To reference this document use: http://resolver.tudelft.nl/uuid:fdd36fee-f5b2-4ab3-93cf-903c1fa866b4 DOI https://doi.org/10.1016/j.tiv.2019.04.005 TNO identifier 866701 ISSN 8872-333 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.