Title
Radiosensitization of biologically active DNA in cellular extracts by oxygen. Evidence that the presence of SH compounds is not required
Author
van Hemmen, J.J.
Meuling, W.J.A.
Bleichrodt, J.F.
Medisch Biologisch Laboratorium TNO
Publication year
1974
Abstract
The radiosensitization by oxygen of biologically active bacteriophage DNA in bacterial extracts was studied. The oxygen effect in such a system appeared not to be due or only to a minor extent to the presence of endogenous sulphydryl compounds. The components in a cell extract which enable oxygen and other sensitizers to sensitize DNA could not be destroyed by extremely high doses of γ radiation. Chemicals/CAS: DNA, 9007-49-2; oxygen, 7782-44-7; thiol derivative, 13940-21-1; Azo Compounds; Cobalt Radioisotopes; Cyclic N-Oxides; Cysteamine, 60-23-1; DNA, Circular; DNA, Viral; Ethylmaleimide, 128-53-0; Oxygen, 7782-44-7; Radiation-Sensitizing Agents; Sulfhydryl Compounds
Subject
Biology
Bacteriophage dna
DNA
Oxygen
Radioisotope
Thiol derivative
Gamma radiation
In vitro study
Methodology
Microorganism
Radiosensitivity
Radiosensitization
Theoretical study
Azo Compounds
Cobalt Radioisotopes
Coliphages
Cyclic N-Oxides
Cysteamine
DNA Viruses
DNA, Circular
DNA, Viral
Dose-Response Relationship, Radiation
Escherichia coli
Ethylmaleimide
Gamma Rays
Mutation
Oxygen
Pseudomonas
Radiation Effects
Radiation-Sensitizing Agents
Sulfhydryl Compounds
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TNO identifier
227740
ISSN
0955-3002
Source
International Journal of Radiation Biology, 26 (6), 547-555
Document type
article