Title
Intestinal absorption of different types of folate in healthy subjects with an ileostomy
Author
Konings, E.J.M.
Troost, F.J.
Castenmiller, J.J.M.
Roomans, H.H.S.
van den Brandt, P.A.
Saris, W.H.M.
Publication year
2002
Abstract
Our knowledge on the absorption of folate is incomplete. The deconjugation process as a possible limiting factor in the absorption of folates was investigated. The study also attempted to validate the use of the area under the serum response curve (AUC) from food compared with folic acid as a proxy variable for food folate bioavailability. Folate absorption was determined in healthy ileostomy volunteers (n 11) using a single-dose short-term protocol. In a randomised crossover design, volunteers received spinach meals and a supplement. Based on analysis of test meals and ileostomy effluents, there was no difference in folate absorption between spinach with a mono-polyglutamate ratio 40:60 and the same spinach with a 100:0 ratio. The absolute absorption of spinach folate (79%) calculated from the difference between folate intake and folate content of ileostomy effluents was approximately equal to the relative absorption (81%) calculated from the AUC after consumption of spinach meals in relation to the AUC after consumption of the folic acid supplement. We conclude that the deconjugation process is not a limiting factor in the absorption of spinach folates. Comparison of AUC of food folate v. folic acid in a short-term protocol may be suitable for assessing food folate bioavailability. Chemicals/CAS: Folic Acid, 59-30-3
Subject
Absorption
Area under the curve
Bioavailability
Folates
Spinach
5 methyltetrahydrofolic acid
Folic acid derivative
Folinic acid
Polyglutamic acid
Area under the curve
Bioavailability
Clinical article
Clinical trial
Conjugation
Controlled clinical trial
Controlled study
Crohn disease
Crossover procedure
Drug absorption
Drug bioavailability
Folate metabolism
Folic acid blood level
Food analysis
Gastrointestinal polyposis
Ileostomy
Neurologic disease
Pelvic disease
Randomized controlled trial
Spinach
Test meal
Ulcerative colitis
Validation process
Vitamin supplementation
Adult
Aged
Area Under Curve
Biological Availability
Cross-Over Studies
Dietary Supplements
Female
Folic Acid
Humans
Ileostomy
Intestinal Absorption
Intestine, Small
Male
Middle Aged
Spinacia oleracea
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DOI
https://doi.org/10.1079/bjn2002613
TNO identifier
280299
ISSN
0007-1145
Source
British Journal of Nutrition, 88 (88), 235-242
Document type
article