Title
Innate, adaptive and regulatory responses in schistosomiasis: Relationship to allergy
Author
Hartgers, F.C.
Smits, H.H.
van der Kleij, D.
Yazdanbakhsh, M.
TNO Defensie en Veiligheid
Publication year
2006
Abstract
Helminth infections have profound effects on the immune system. Here, recent insights in the molecular interactions between schistosomes and the host are described with respect to adaptive but also with respect to innate immune responses. Furthermore, the different mechanisms of immune hyporesponsiveness are depicted with emphasis on regulatory T cells. Finally, the relationship between downregulatory responses and allergy is discussed. Copyright © 2006 S. Karger AG.
Subject
Anthelmintic agent
Immunoglobulin G4
Intercellular adhesion molecule 3
Interleukin 13 receptor
Pattern recognition receptor
STAT1 protein
Tetanus toxoid
Toll like receptor 1
Toll like receptor 3
Toll like receptor 5
Toll like receptor 6
Toll like receptor 7
Toll like receptor 8
Allergy
Antibody production
Antigen specificity
Atopy
Brugia malayi
CD4+ CD25+ T lymphocyte
Cellular immunity
Chronic disease
Clonal anergy
Cross tolerance
Dendritic cell
Down regulation
Endemic disease
Helicobacter pylori
Helminthiasis
Human
Immune deficiency
Immune response
Immunoregulation
Inflammation
Innate immunity
Lymphocyte proliferation
Mast cell degranulation
Molecular interaction
Nippostrongylus brasiliensis
Nonhuman
Regulatory T lymphocyte
Review
Schistosoma
Schistosoma hematobium
Schistosoma mansoni
Schistosomiasis
Sensitization
T lymphocyte activation
T lymphocyte subpopulation
Tetanus
Th1 cell
Th2 cell
Upregulation
Animals
Chronic Disease
Hypersensitivity
Immune Tolerance
Immunity, Natural
Interleukin 13, 148157-34-0
Tetanus toxoid, 57425-69-1, 93384-51-1
Toll like receptor 2, 203811-81-8
Toll like receptor 4, 203811-83-0
Toll like receptor 9, 352486-49-8, 390883-32-6
Toll like receptor, 409141-78-2
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TNO identifier
183153
ISSN
1660-2242
Source
Chemical Immunology and Allergy, 90, 157-175
Document type
article