Title
Temporal relation between ischemic episodes and activation of the coagulation system in unstable angina
Author
TNO Preventie en Gezondheid
Biasucci, L.M.
Liuzzo, G.
Caligiuri, G.
Quaranta, G.
Andreotti, F.
Sperti, G.
van de Greef, W.
Rebuzzi, A.G.
Kluft, C.
Maseri, A.
Publication year
1996
Abstract
Background: Although a major role of coronary thrombosis in the pathogenesis of unstable angina has been demonstrated, the results of a series of studies have suggested that activation of the hemostatic system may not be confined to ischemic episodes. The purpose of this study was to investigate the temporal relation between ischemic episodes and activation of the coagulation system in unstable angina. Methods and Results: Thrombin- antithrombin III (TAT) and prothrombin fragment 1 + 2 (F1+2) levels were measured in 13 patient souring spontaneous ischemic episodes (time 0, 5, and 15 minutes and 1 hour) to evaluate the time course of the activation of the coagulation system associated with the development of ischemia (protocol A). TAT and F1+2 levels were also measured in 28 patient with unstable angina on admission to hospital (every 6 hours for 24 hours and daily for 3 days) to assess their temporal relation with ischemic episodes (protocol B). In protocol A, TAT and F1+2 levels were elevated in 10 of 13 patients (77%) in at least 1 sample. The median value of TAT showed a peak at 5 minutes and returned to baseline within 15 minutes (P
Subject
angina
coagulation
ischemia
antithrombin iii
prothrombin
thrombin
adult
aged
angiocardiography
article
blood clotting
clinical article
controlled study
coronary artery thrombosis
female
human
male
priority journal
protein blood level
unstable angina pectoris
Adult
Aged
Angina, Unstable
Antithrombin III
Blood Coagulation
Female
Humans
Male
Middle Aged
Myocardial Ischemia
Peptide Fragments
Peptide Hydrolases
Prothrombin
Time Factors
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TNO identifier
233363
ISSN
0009-7322
Source
Circulation, 93 (93), 2121-2127
Document type
article