Title
Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer
Author
Kim, D.H.
Smith-Warner, S.A.
Spiegelman, D.
Yaun, S.S.
Colditz, G.A.
Freudenheim, J.L.
Giovannucci, E.
Goldbohm, R.A.
Graham, S.
Harnack, L.
Jacobs, E.J.
Leitzmann, M.
Mannisto, S.
Miller, A.B.
Potter, J.D.
Rohan, T.E.
Schatzkin, A.
Speizer, F.E.
Stevens, V.L.
Stolzenberg-Solomon, R.
Terry, P.
Toniolo, P.
Weijenberg, M.P.
Willett, W.C.
Wolk, A.
Zeleniuch-Jacquotte, A.
Hunter, D.J.
TNO Kwaliteit van Leven
Publication year
2010
Abstract
Objective: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Methods: Study-and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. Results: Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing ≥560 mcg/days vs. <240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 μg/day increase in total folate intake. Conclusion: These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer. © 2010 Springer Science+Business Media B.V.
Subject
Health
Leefomgeving en gezondheid
Cohort studies
Colon cancer
Folate
Meta-analysis
Pooled analysis
To reference this document use:
http://resolver.tudelft.nl/uuid:ee674821-47e9-4080-9df5-49e88558442b
TNO identifier
425497
ISSN
0957-5243
Source
Cancer Causes and Control, 21 (11), 1919-1930
Document type
article