Print Email Facebook Twitter Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer Title Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer Author Kim, D.H. Smith-Warner, S.A. Spiegelman, D. Yaun, S.S. Colditz, G.A. Freudenheim, J.L. Giovannucci, E. Goldbohm, R.A. Graham, S. Harnack, L. Jacobs, E.J. Leitzmann, M. Mannisto, S. Miller, A.B. Potter, J.D. Rohan, T.E. Schatzkin, A. Speizer, F.E. Stevens, V.L. Stolzenberg-Solomon, R. Terry, P. Toniolo, P. Weijenberg, M.P. Willett, W.C. Wolk, A. Zeleniuch-Jacquotte, A. Hunter, D.J. TNO Kwaliteit van Leven Publication year 2010 Abstract Objective: Studies of folate intake and colorectal cancer risk have been inconsistent. We examined the relation with colon cancer risk in a series of 13 prospective studies. Methods: Study-and sex-specific relative risks (RRs) were estimated from the primary data using Cox proportional hazards models and then pooled using a random-effects model. Results: Among 725,134 participants, 5,720 incident colon cancers were diagnosed during follow-up. The pooled multivariate RRs (95% confidence interval [CI]) comparing the highest vs. lowest quintile of intake were 0.92 (95% CI 0.84-1.00, p-value, test for between-studies heterogeneity = 0.85) for dietary folate and 0.85 (95% CI 0.77-0.95, p-value, test for between-studies heterogeneity = 0.42) for total folate. Results for total folate intake were similar in analyses using absolute intake cutpoints (pooled multivariate RR = 0.87, 95% CI 0.78-0.98, comparing ≥560 mcg/days vs. <240 mcg/days, p-value, test for trend = 0.009). When analyzed as a continuous variable, a 2% risk reduction (95% CI 0-3%) was estimated for every 100 μg/day increase in total folate intake. Conclusion: These data support the hypothesis that higher folate intake is modestly associated with reduced risk of colon cancer. © 2010 Springer Science+Business Media B.V. Subject HealthLeefomgeving en gezondheidCohort studiesColon cancerFolateMeta-analysisPooled analysis To reference this document use: http://resolver.tudelft.nl/uuid:ee674821-47e9-4080-9df5-49e88558442b TNO identifier 425497 ISSN 0957-5243 Source Cancer Causes and Control, 21 (11), 1919-1930 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.