Title
Protein supplementation lowers blood pressure in overweight adults: Effect of dietary proteins on blood pressure (PROPRES), a randomized trial
Author
Teunissen-Beekman, K.F.M.
Dopheide, J.
Geleijnse, J.M.
Bakker, S.J.L.
Brink, E.J.
de Leeuw, P.W.
van Baak, M.A.
Publication year
2012
Abstract
Background: Dietary protein intake may help to manage blood pressure (BP) and prevent complications associated with elevated BP. Objective: The objective of this study was to determine whether 4 wk of increased protein intake (∼25% compared with ;15% of energy intake that isoenergetically replaces carbohydrate intake) lowers office and daytime BP compared with increased carbohydrate intake. Design: A randomized, double-blind, parallel study compared consumption of 3 x 20 g protein/d (20% pea, 20% soy, 30% egg, and 30% milk-protein isolate) with 3 x 20 g maltodextrin/d. Protein or maltodextrin were isoenergetically substituted for a sugar-sweetened drink. Primary outcomes were office and daytime BP. A total of 99 men and women [age range: 20-70 y; BMI (in kg/m2): 25-35] with untreated elevated BP (BP ≥130/85 and <160/100 mm Hg) were randomly assigned. Ninety-four completers (51 subjects in the maltodextrin group, 43 subjects in the protein group) were included in the analyses. Results: Office systolic blood pressure (SBP) and diastolic blood pressure (DBP) were 4.9 ± 1.7 mmHg (P = 0.005) and 2.7 ± 1.3 mm Hg (P = 0.05) lower, respectively, in the protein group. Daytime SBP was 4.6 ± 1.7 mm Hg lower in the protein group (P = 0.006), whereas daytime DBP did not differ between groups (P = 0.37). Urinary sodium excretion was higher in the maltodextrin group (P = 0.004). Conclusion: Increased protein intake, at the expense of maltodextrin, lowers BP in overweight adults with upper-range prehypertension and grade 1 hypertension. This trial was registered at www. trialregister.nl as NTR 1362. © 2012 American Society for Nutrition.
Subject
Life
PHS - Pharmacokinetics & Human Studies
EELS - Earth, Environmental and Life Sciences
Healthy for Life
Biology
Healthy Living
To reference this document use:
http://resolver.tudelft.nl/uuid:e8502301-f5bb-4d6a-ba81-58fcd63133ba
DOI
https://doi.org/10.3945/ajcn.111.029116
TNO identifier
448199
ISSN
0002-9165
Source
American Journal of Clinical Nutrition, 95 (4), 966-971
Document type
article