Title
HDL cholesterol efflux normalised to apoA-I is associated with future development of type 2 diabetes: From the CORDIOPREV trial
Author
Blanco-Rojo, R.
Perez-Martinez, P.
Lopez-Moreno, J.
Martinez-Botas, J.
Delgado-Lista, J.
van Ommen, B.
Yubero-Serrano, E.
Camargo, A.
Ordovas, J.M.
Perez-Jimenez, F.
Gomez-Coronado, D.
Lopez-Miranda, J.
Publication year
2017
Abstract
This prospective study evaluated whether baseline cholesterol efflux is associated with future development of type 2 diabetes (T2DM) in cardiovascular patients. We measured cholesterol efflux in all CORDIOPREV study (NCT00924937) participants free of T2DM at baseline (n = 462) and assessed its relationship with T2DM incidence during a 4.5 years of follow-up. Cholesterol efflux was quantified by incubation of cholesterol-loaded THP-1 cells with the participants' apoB-depleted plasma. Disposition index was estimated as beta-cell function indicator. During follow-up 106 individuals progressed to T2DM. The cholesterol efflux/apoA-1 ratio was inversely associated with T2DM development independently of traditional risk factors (model-1, OR: 0.647, 95%CI: 0.495-0.846), and after additional adjustment for glycaemic parameters (model-2, OR: 0.670, 95%CI: 0.511-0.878). When cumulative incidence of diabetes was analysed by quartiles of cholesterol efflux/apoA-I, incidence of T2DM was reduced by 54% in subjects who were in the higher cholesterol efflux/apoA-I quartile compared to subjects in the lowest quartile (p = 0.018 and p = 0.042 for model-1 and 2). Moreover, participants who were in the higher cholesterol efflux/apoA-I presented significantly higher disposition index (beta = 0.056, SE = 0.026; p = 0.035). In conclusion, HDL-cholesterol efflux normalised to apoA-I was inversely associated with T2DM development in cardiovascular patients. This association was independent of several T2DM risk factors, and may be related to a preserved beta-cell function. © 2017 The Author(s).
Subject
ELSS - Earth, Life and Social Sciences
Life
Healthy Living
Biomedical Innovation
Biology
MSB - Microbiology and Systems Biology
To reference this document use:
http://resolver.tudelft.nl/uuid:d9cb0a05-5b2b-40ba-9308-408d0677758c
DOI
https://doi.org/10.1038/s41598-017-12678-9
TNO identifier
781375
ISSN
2045-2322
Source
Scientific Reports, 7 (7)
Document type
article