Title
Behavioral effects of modafinil in marmoset monkeys
Author
TNO Defensie en Veiligheid
van Vliet, S.A.M.
Jongsma, M.J.
Vanwersch, R.A.P.
Olivier, B.
Philippens, I.H.C.H.M.
Publication year
2006
Abstract
Rationale: Modafinil is increasingly used in sleep disturbances in general and in neurodegenerative diseases and is recently being used in healthy people for attention control. However, the application of modafinil is possibly not only restricted to alertness enhancing effects. More insight in this compound may lead to new applications. Not all behavioral aspects have been studied sufficiently; therefore, more detailed investigations on modafinil's positive and aversive behavioral effects are addressed in this paper. Objectives: Determination of effects of modafinil in marmoset monkeys with observational methods and with behavioral tests measuring locomotor activity, hand-eye coordination, response to a threat situation and startle response. Materials and methods: Two hours after oral administration of modafinil in doses of 50, 100, 150, and 225 mg/kg, animals were observed and tested in the behavioral test systems. Results: Locomotor activity was increased after 100 mg/ kg modafinil in the Bungalow test and after 100, 150, and 225 mg/kg, as found in the movement parameters of the human threat test. Moreover, modafinil snowed anxiolytic-like effects in the human threat test. No other side effects were observed, nor were the hand-eye coordination and startle response affected. Conclusions: Besides psychostimulation, modafinil has no aversive effects in the doses used in the domains measured. The potential anxiolytic-like effects of modafinil may create new possibilities for the therapeutic use of modafinil. © Springer-Verlag 2006.
Subject
Activity
Anxiety
Behavior
Hand-eye coordination
Marmoset monkey
Modafinil
Side effects
Startle reflex
Alertness
Animal experiment
Attention
Aversion
Controlled study
Dose response
Eye hand coordination
Female
Locomotion
Male
Marmoset
Monkey
Nonhuman
Sleep disorder
Startle reflex
Threat
Tranquilizing activity
Acoustic Stimulation
Animals
Anxiety
Behavior, Animal
Benzhydryl Compounds
Callithrix
Central Nervous System Stimulants
Dose-Response Relationship, Drug
Exploratory Behavior
Motor Activity
Psychomotor Performance
Startle Reaction
Modafinil, 68693-11-8
Benzhydryl Compounds
Central Nervous System Stimulants
To reference this document use:
http://resolver.tudelft.nl/uuid:d2cb1d4f-6a6b-411e-bcc8-0a47d7844a88
DOI
https://doi.org/10.1007/s00213-006-0340-4
TNO identifier
183571
ISSN
0033-3158
Source
Psychopharmacology, 185 (185), 433-440
Document type
article