Title
Spontaneous ultra-weak photon emission in correlation to inflammatory metabolism and oxidative stress in a mouse model of collagen-induced arthritis
Author
He, M.
van Wijk, E.
van Wietmarschen, H.
Wang, M.
Sun, M.
Koval, S.
van Wijk, R.
Hankemeier, T.
van der Greef, J.
Publication year
2017
Abstract
The increasing prevalence of rheumatoid arthritis has driven the development of new approaches and technologies for investigating the pathophysiology of this devastating, chronic disease. From the perspective of systems biology, combining comprehensive personal data such as metabolomics profiling with ultra-weak photon emission (UPE) data may provide key information regarding the complex pathophysiology underlying rheumatoid arthritis. In this article, we integrated UPE with metabolomics-based technologies in order to investigate collagen-induced arthritis, a mouse model of rheumatoid arthritis, at the systems level, and we investigated the biological underpinnings of the complex dataset. Using correlation networks, we found that elevated inflammatory and ROS-mediated plasma metabolites are strongly correlated with a systematic reduction in amine metabolites, which is linked to muscle wasting in rheumatoid arthritis. We also found that increased UPE intensity is strongly linked to metabolic processes (with correlation co-efficiency | r | value > 0.7), which may be associated with lipid oxidation that related to inflammatory and/or ROS-mediated processes. Together, these results indicate that UPE is correlated with metabolomics and may serve as a valuable tool for diagnosing chronic disease by integrating inflammatory signals at the systems level. Our correlation network analysis provides important and valuable information regarding the disease process from a system-wide perspective.
Subject
Life
MSB - Microbiology and Systems Biology
EELS - Earth, Environmental and Life Sciences
Biomedical Innovation
Biology
Healthy Living
Collagen-induced arthritis
Correlation networks
Systems biology
Metabolomics
Ultra-weak photon emission
To reference this document use:
http://resolver.tudelft.nl/uuid:cfe664ac-42f0-4d2d-b0d3-d04c28a4f070
DOI
https://doi.org/10.1016/j.jphotobiol.2016.12.036
TNO identifier
745557
ISSN
1011-1344
Source
Journal of Photochemistry and Photobiology B: Biology, 168, 98-106
Document type
article