Title
Current challenges facing the assessment of the allergenic capacity of food allergens in animal models
Author
Bøgh, K.L.
van Bilsen, J.
Głogowski, R.
López-Expósito, I.
Bouchaud, G.
Blanchard, C.
Bodinier, M.
Smit, J.
Pieters, R.
Bastiaan-Net, S.
de Wit, N.
Untersmayr, E.
Adel-Patient, K.
Knippels, L.
Epstein, M.M.
Noti, M.
Nygaard, U.C.
Kimber, I.
Verhoeckx, K.
O'Mahony, L.
Publication year
2016
Abstract
Food allergy is a major health problem of increasing concern. The insufficiency of protein sources for human nutrition in a world with a growing population is also a significant problem. The introduction of new protein sources into the diet, such as newly developed innovative foods or foods produced using new technologies and production processes, insects, algae, duckweed, or agricultural products from third countries, creates the opportunity for development of new food allergies, and this in turn has driven the need to develop test methods capable of characterizing the allergenic potential of novel food proteins. There is no doubt that robust and reliable animal models for the identification and characterization of food allergens would be valuable tools for safety assessment. However, although various animal models have been proposed for this purpose, to date, none have been formally validated as predictive and none are currently suitable to test the allergenic potential of new foods. Here, the design of various animal models are reviewed, including among others considerations of species and strain, diet, route of administration, dose and formulation of the test protein, relevant controls and endpoints measured. © 2016 Bøgh et al.
Subject
ELSS - Earth, Life and Social Sciences
Life
Healthy Living
Food and Nutrition
Animal models
Food allergy
Hazard identification
Novel allergens
RAPID - Risk Analysis for Products in Development
To reference this document use:
http://resolver.tudelft.nl/uuid:cc12eeaf-6e1d-4a9c-8102-93c83ae935ff
DOI
https://doi.org/10.1186/s13601-016-0110-2
TNO identifier
575663
ISSN
2045-7022
Source
Clinical and Translational Allergy, 6 (6)
Document type
article