Title
Lactotripeptides and antihypertensive effects: A critical review
Author
TNO Kwaliteit van Leven
Boelsma, E.
Kloek, J.
Publication year
2009
Abstract
Hypertension or high blood pressure is a significant health problem worldwide. Typically, lifestyle changes, including adopting a healthy diet, are recommended for people with an elevated blood pressure. Lactotripeptides are bioactive milk peptides with potential antihypertensive properties in man. These peptides, as part of a food product or as nutraceutical, may contribute to the prevention and treatment of hypertension. This paper reviews the current evidence of the blood pressure control properties of lactotripeptides in man. Blood pressure-lowering effects of lactotripeptides are typically measured after 4-6 weeks of treatment. However, in some cases, a blood pressure response has been observed after 1-2 weeks. Maximum blood pressure reductions approximate 13 mmHg (systolic blood pressure) and 8 mmHg (diastolic blood pressure) after active treatment compared with placebo, and are likely reached after 8-12 weeks of treatment. Effective dosages of lactotripeptides range from 3.07 to 52.5 mg/d. Evidence indicates that lactotripeptides are only effective at elevated blood pressure; no further lowering of normal blood pressure has been observed. Concomitant intake of antihypertensive medication does not seem to influence the potency of lactotripeptides to lower blood pressure. Similarly, ethnicity has not been found to influence the extent of lactotripeptide-induced blood pressure lowering. Based on the currently available data, lactotripeptides appear to be safe and effective. Thus, they can be part of a healthy diet and lifestyle to prevent or reduce high blood pressure.
Subject
Biomedical Research
Antihypertensive effects
Blood pressure
Lactotripeptides
Milk peptides
antihypertensive agent
Beta adrenergic receptor blocking agent
Calcium antagonist
Dipeptidyl carboxypeptidase inhibitor
Lactotripeptide derivative
Placebo
Unclassified drug
Absence of side effects
Antihypertensive activity
Antihypertensive therapy
Blood chemistry
Blood pressure regulation
Caucasian
Clinical trial
Diastolic blood pressure
Dose response
Dose time effect relation
Drug bioavailability
Drug efficacy
Drug megadose
Drug potency
Drug safety
Food intake
Human
Hypertension
Japanese
Low drug dose
Nonhuman
Race difference
Review
Side effect
Systolic blood pressure
Treatment duration
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DOI
https://doi.org/10.1017/s0007114508137722
TNO identifier
241632
ISSN
0007-1145
Source
British Journal of Nutrition, 101 (101), 776-786
Document type
article