Print Email Facebook Twitter Animal model of human disease. Multiple myeloma Title Animal model of human disease. Multiple myeloma Author Radl, J. Croese, J.W. Zurcher, C. van den Enden-Vieveen, M.H.M. de Leeuw, A.M. Instituut voor Experimentele Gerontologie TNO Publication year 1988 Abstract Animal models of spontaneous and induced plasmacytomas in some inbred strains of mice have proven to be useful tools for different studies on tumorigenesis and immunoregulation. Their wide applicability and the fact that after their intravenous transplantation, the recipient mice developed bone lesions, led in some instances to an incorrect use of the term myeloma for these neoplasms. They originate and grow as extramedullary plasmacytomas, mostly without involvement of the bone marrow. Therefore, they cannot be compared with the most frequent plasma cell malignancy in humans, the multiple myeloma (MM). A more appropriate model for MM is available in aging mice of the C57BL/KaLwRij strain. Subject Healthanimal cellanimal experimentanimal modelhistochemistryhistologyimmunocytomamultiple myelomanonhumanplasmacytomaAgingAnimalDisease Models, AnimalHumanMiceMice, Inbred BALB CMice, Inbred C57BLMultiple MyelomaSupport, U.S. Gov't, P.H.S. To reference this document use: http://resolver.tudelft.nl/uuid:c908c2f0-df84-4325-ba5d-463c6cd52873 TNO identifier 230628 ISSN 0002-9440 Source American Journal of Pathology, 132 (3), 593-597 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.