Title
Plasma coenzyme Q10 concentrations are not decreased in male patients with coronary atherosclerosis
Author
van de Vijver, L.P.L.
Weber, C.
Kardinaal, A.F.M.
Grobbee, D.E.
Princen, H.M.G.
van Poppel, G.
Centraal Instituut voor Voedingsonderzoek TNO TNO Voeding
Publication year
1999
Abstract
Coenzyme Q10 (CoQ10) is an important mitochondrial electron transfer component and has been postulated to function as a powerful antioxidant protecting LDL from oxidative damage. It could thus reduce the risk of cardiovascular disease. Thus far, beneficial effects of supplementation with CoQ10 have been reported. To study the relation between unsupplemented concentrations of plasma CoQ10 and coronary atherosclerosis, we performed a case-control study among 71 male cases with angiographically documented severe coronary atherosclerosis and 69 healthy male controls free from symptomatic cardiovascular disease and without atherosclerotic plaques in the carotid artery. Plasma CoQ10 concentrations (mean ± SE) were 0.86 ± 0.04 vs. 0.83 ± 0.04 μmol/l for cases and controls, respectively. The CoQ10/LDL-cholesterol ratio (μmol/mmol) was slightly lower in cases than in controls (0.22 ± 0.01 vs. 0.26 ± 0.03). Differences in CoQ10 concentrations and CoQ10/LDL-cholesterol ratio did not reach significance. The odds ratios (95% confidence interval) for the risk of coronary atherosclerosis calculated per μmol/l increase of CoQ10 was 1.12 (0.28-4.43) after adjustment for age, smoking habits, total cholesterol and diastolic blood pressure. We conclude that an unsupplemented plasma CoQ10 concentration is not related to risk of coronary atherosclerosis. Chemicals/CAS: ubidecarenone, 303-98-0; Antioxidants; Cholesterol, LDL; coenzyme Q10, 303-98-0; Ubiquinone, 1339-63-5
Subject
Nutrition
Antioxidants
Coenzyme Q10
Coronary atherosclerosis
LDL oxidation
Plasma
Ubiquinol
Low density lipoprotein cholesterol
Ubidecarenone
Antioxidant
Drug derivative
Ubiquinone
Adult
Aged
Angiocardiography
Cholesterol blood level
Controlled study
Coronary artery atherosclerosis
Diastolic blood pressure
Major clinical study
Smoking habit
Blood
Case control study
Electron transport
Metabolism
Oxidation reduction reaction
Aged
Antioxidants
Case-Control Studies
Cholesterol, LDL
Coronary Arteriosclerosis
Electron Transport
Humans
Male
Middle Aged
Oxidation-Reduction
Risk Factors
Ubiquinone
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TNO identifier
234887
ISSN
1071-5762
Source
Free Radical Research, 30 (3), 165-172
Document type
article