Title
Modulation of the cytokine network in human adult astrocytes by human herpesvirus-6A
Author
Meeuwsen, S.
Persoon-Deen, C.
Bsibsi, M.
Bajramovic, J.J.
Ravid, R.
de Bolle, L.
van Noort, J.M.
Gaubius Instituut TNO
Publication year
2005
Abstract
Human herpesvirus-6A (HHV-6A) is a common pathogen whose role in CNS disorders including multiple sclerosis remains controversial. To understand how HHV-6A could influence inflammatory pathways in the CNS, we infected cultured human adult astrocytes and examined the expression of 268 cytokines, chemokines, growth factors and their receptors by gene profiling. HHV-6 infection alone had little effect on the astrocyte gene profile but strongly altered the astrocyte response to proinflammatory cytokines. Under those conditions astrocytes express higher levels of anti-inflammatory mediators including IL-10 and IL-11, chemotactic factors, growth factors and factors controlling type I interferon production. Our data suggest that HHV-6 itself does not evoke a pro-inflammatory response in astrocytes but rather triggers immune modulatory factors in the face of inflammation. © 2005 Elsevier B.V. All rights reserved. Chemicals / CAS: Cytokines; DAPI, 47165-04-8; Glial Fibrillary Acidic Protein; Growth Substances; Indoles; Receptors, Cytokine; Receptors, Growth Factor
Subject
Astrocytes
Cytokines
Gene profiling
HHV-6
Inflammation
chemokine
chemotactic factor
growth factor
growth factor receptor
interleukin 10
interleukin 11
aged
controlled study
cytokine production
female
gene expression profiling
human cell
human cell culture
Human herpesvirus 6
human tissue
immune response
immunomodulation
inflammation
nucleotide sequence
priority journal
protein expression
unindexed sequence
virus infection
Astrocytes
Brain
Cells, Cultured
Cytokines
Gene Expression Profiling
Gene Expression Regulation
Glial Fibrillary Acidic Protein
Growth Substances
Herpesvirus 6, Human
Humans
Indoles
Models, Biological
Receptors, Cytokine
Receptors, Growth Factor
Regression Analysis
T-Lymphocytes
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http://resolver.tudelft.nl/uuid:b403cd00-6815-4ef5-ac9d-534aeb2f9aae
DOI
https://doi.org/10.1016/j.jneuroim.2005.03.013
TNO identifier
238594
ISSN
0165-5728
Source
Journal of Neuroimmunology, 164 (1-2), 37-47
Document type
article