Title
Moderate alcohol consumption reduces plasma C-reactive protein and fibrinogen levels: A randomized, diet-controlled intervention study
Author
Sierksma, A.
van der Gaag, M.S.
Kluft, C.
Hendriks, H.F.J.
TNO Voeding
Publication year
2002
Abstract
Objective: To evaluate the effect of moderate alcohol consumption on the acute phase proteins C-reactive protein and fibrinogen. Design: Randomized, diet-controlled, cross-over study. Setting: The study was performed at TNO Nutrition and Food Research, Zeist, The Netherlands. Subjects: Ten middle-aged men and 10 postmenopausal women, all apparently healthy, non-smoking and moderate alcohol drinkers, were included. One women dropped out because of a treatment-unrelated cause. The remaining 19 subjects finished the experiment successfully. Interventions: Men consumed four glasses and women consumed three glasses of beer or no-alcohol beer (control) with evening dinner during two successive periods of 3 weeks. The total diet was supplied to the subjects and had essentially the same composition during these 6 weeks. Before each treatment there was a 1 week washout period to compensate for possible carry-over effects. Results: Plasma C-reactive protein and fibrinogen levels were decreased by 35% (P = 0.02) and 12.4% (P ≤ 0.001), respectively, after 3 weeks' consumption of beer, as compared to no-alcohol beer consumption. Conclusions: Moderate alcohol consumption significantly decreased plasma C-reactive protein and fibrinogen levels. An anti-inflammatory action of alcohol may help explain the link between moderate alcohol consumption and lower cardiovascular disease risk.
Subject
Nutrition
Alcohol
Atherosclerosis
C-reactive protein
Fibrinogen
Inflammation
Acetylsalicylic acid
Acute phase protein
Alanine aminotransferase
Aspartate aminotransferase
Estradiol
Follitropin
Gamma glutamyltransferase
Glucose
Hemoglobin
High density lipoprotein cholesterol
Low density lipoprotein cholesterol
Paracetamol
Triacylglycerol
Adult
Alcohol consumption
Antiinflammatory activity
Cardiovascular risk
Cigarette smoking
Clinical trial
Controlled clinical trial
Controlled study
Crossover procedure
Diet therapy
Fibrinogen blood level
Food composition
Human experiment
Netherlands
Postmenopause
Protein blood level
Randomized controlled trial
Alcohol Drinking
Beer
C-Reactive Protein
Cardiovascular Diseases
Cholesterol, HDL
Cross-Over Studies
Diet
Female
Humans
Liver
Male
Middle Aged
Postmenopause
Triglycerides
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http://resolver.tudelft.nl/uuid:b1b9fbb7-c11f-48b1-ae1a-7ff0cf2319e0
DOI
https://doi.org/10.1038/sj.ejcn.1601459
TNO identifier
87748
Source
European Journal of Clinical Nutrition, 56 (11), 1130-1136
Document type
article