Title
Anthropometry, physical activity, and endometrial cancer risk: Results from the Netherlands Cohort Study
Author
Schouten, L.J.
Goldbohm, R.A.
van den Brandt, P.A.
TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO
Publication year
2004
Abstract
Although obesity is an established risk factor for endometrial cancer, evidence linking risk to height, weight change since age 20, and physical activity is limited. In this case-cohort study, 62 573 women from The Netherlands Cohort Study on Diet and Cancer were followed up from 1986 to 1995, and 226 endometrial cancer case patients were identified. In Cox proportional hazards analyses, women 175 cm or taller had an increased risk of endometrial cancer compared with those less than 160 cm (rate ratio [RR] = 2.57, 95% confidence interval [CI] = 1.32 to 4.99). Compared with women with a body mass index (BMI; kg/m2 between 20 and 22.9, women with a BMI of 30 or greater had a higher risk (RR = 4.50, 95% CI = 2.62 to 7.72; Ptrend<.001). Moreover, BMI at age 20 and BMI gain since age 20 were positively associated with endometrial cancer risk (Ptrend = .02 and <.001, respectively). Women who spent 90 minutes per day or more doing nonoccupational physical activities had a lower risk (RR = 0.54, 95% CI = 0.34 to 0.85; Ptrend = .002) compared with those who spent less than 30 minutes per day. High BMI and low physical activity were strong and independent risk factors for endometrial cancer. © Oxford University Press 2004, all rights reserved.
Subject
Health
Food and Chemical Risk Analysis
Cancer risk
Confidence interval
Controlled study
Endometrium cancer
Evidence based medicine
Female
Follow up
High risk population
Major clinical study
Nonbiological model
Obesity
Physical activity
Case control study
Cohort analysis
Endometrium tumor
Feeding behavior
Proportional hazards model
Risk
Adult
Aged
Anthropometry
Body Height
Body Mass Index
Body Weight
Case-Control Studies
Cohort Studies
Endometrial Neoplasms
Female
Food Habits
Humans
Middle Aged
Motor Activity
Multivariate Analysis
Netherlands
Odds Ratio
Proportional Hazards Models
To reference this document use:
http://resolver.tudelft.nl/uuid:b1323988-89a5-4fc8-84e0-43d87d97030b
DOI
https://doi.org/10.1093/jnci/djh291
TNO identifier
238087
ISSN
0027-8874
Source
Journal of the National Cancer Institute, 96 (21), 1635-1638
Document type
article