Print Email Facebook Twitter Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies Title Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies Author Männistö, S. Smith-Warner, S.A. Spiegelman, D. Albanes, D. Anderson, K. van den Brandt, P.A. Cerhan, J.R. Colditz, G. Feskanich, D. Freudenheim, J.L. Giovannucci, E. Goldbohm, R.A. Graham, S. Miller, A.B. Rohan, T.E. Virtamo, J. Willett, W.C. Hunter, D.J. TNO Voeding Centraal Instituut voor Voedingsonderzoek TNO Publication year 2004 Abstract Intervention trials with supplemental β-carotene have observed either no effect or a harmful effect on lung cancer risk. Because food composition databases for specific carotenoids have only become available recently, epidemiological evidence relating usual dietary levels of these carotenoids with lung cancer risk is limited. We analyzed the association between lung cancer risk and intakes of specific carotenoids using the primary data from seven cohort studies in North America and Europe. Carotenoid intakes were estimated from dietary questionnaires administered at baseline in each study. We calculated study-specific multivariate relative risks (RRs) and combined these using a random-effects model. The multivariate models included smoking history and other potential risk factors. During follow-up of up to 7-16 years across studies, 3,155 incident lung cancer cases were diagnosed among 399,765 participants. β-Carotene intake was not associated with lung cancer risk (pooled multivariate RR = 0.98; 95% confidence interval, 0.87-1.11; highest versus lowest quintile). The RRs for α-carotene, lutein/zeaxanthin, and lycopene were also close to unity. β-Cryptoxanthin intake was inversely associated with lung cancer risk (RR = 0.76; 95% confidence interval, 0.67-0. 86; highest versus lowest quintile). These results did not change after adjustment for intakes of vitamin C (with or without supplements), folate (with or without supplements), and other carotenoids and multivitamin use. The associations generally were similar among never, past, or current smokers and by histological type. Although smoking is the strongest risk factor for lung cancer, greater intake of foods high in β-cryptoxanthin, such as citrus fruit, may modestly lower the risk. Subject HealthFood and Chemical Risk AnalysisAlpha caroteneAscorbic acidBeta caroteneCarotenoidCryptoxanthinFolic acidLycopeneXanthophyllZeaxanthinAdultAgedCancer preventionCancer riskCitrus fruitCohort analysisDietary intakeEuropeFemaleFood compositionHumanLung cancerMajor clinical studyMaleNorth AmericaPriority journalQuestionnaireRisk factorSmokingCarotenoidsCohort StudiesConfidence IntervalsDietEuropeFemaleHumansLung NeoplasmsMaleNorth AmericaQuestionnairesRegistriesRisk FactorsSmoking To reference this document use: http://resolver.tudelft.nl/uuid:b01dc6f3-01f2-4be2-bb79-462d96655931 DOI https://doi.org/10.1158/1055-9965.epi-038-3 TNO identifier 237578 ISSN 1055-9965 Source Cancer Epidemiology Biomarkers and Prevention, 13 (1), 40-48 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.