Title
Short-term fatty acid intervention elicits differential gene expression responses in adipose tissue from lean and overweight men
Author
TNO Kwaliteit van Leven
van Erk, M.J.
Pasman, W.J.
Wortelboer, H.M.
van Ommen, B.
Hendriks, H.F.J.
Publication year
2008
Abstract
The goal of this study was to investigate the effect of a short-term nutritional intervention on gene expression in adipose tissue from lean and overweight subjects. Gene expression profiles were measured after consumption of an intervention spread (increased levels of polyunsaturated fatty acids, conjugated linoleic acid and medium chain triglycerides) and a control spread (40 g of fat daily) for 9 days. Adipose tissue gene expression profiles of lean and overweight subjects were distinctly different, mainly with respect to defense response and metabolism. The intervention resulted in lower expression of genes related to energy metabolism in lean subjects, whereas expression of inflammatory genes was down-regulated and expression of lipid metabolism genes was up-regulated in the majority of overweight subjects. Individual responses in overweight subjects were variable and these correlated better to waist-hip ratio and fat percentage than BMI. © 2008 The Author(s).
Subject
Biomedical Research
Conjugated linoleic acid (CLA)
Medium chain triglycerides
Microarray
Polyunsaturated fatty acids (PUFA)
Subcutaneous adipose tissue
To reference this document use:
http://resolver.tudelft.nl/uuid:aa07a21d-cea0-4650-be9d-6bad47ebe19d
DOI
https://doi.org/10.1007/s12263-008-0096-z
TNO identifier
241143
ISSN
1555-8932
Source
Genes and Nutrition, 3 (3), 127-137
Document type
article