Print Email Facebook Twitter A novel safety assessment strategy applied to non-selective extracts Title A novel safety assessment strategy applied to non-selective extracts Author Koster, S. Leeman, W.R. Verheij, E.R. Dutman, A.E. van Stee, L.L.P. Munch Nielsen, L. Ronsmans, S. Noteborn, H. Krul, L. Publication year 2015 Abstract A main challenge in food safety research is to demonstrate that processing of foodstuffs does not lead to the formation of substances for which the safety upon consumption might be questioned. This is especially so since food is a complex matrix in which the analytical detection of substances, and consequent risk assessment thereof, is difficult to determine. Here, a pragmatic novel safety assessment strategy is applied to the production of non-selective extracts (NSEs), used for different purposes in food such as for colouring purposes, which are complex food mixtures prepared from reference juices. The Complex Mixture Safety Assessment Strategy (CoMSAS) is an exposure driven approach enabling to efficiently assess the safety of the NSE by focussing on newly formed substances or substances that may increase in exposure during the processing of the NSE. CoMSAS enables to distinguish toxicologically relevant from toxicologically less relevant substances, when related to their respective levels of exposure. This will reduce the amount of work needed for identification, characterisation and safety assessment of unknown substances detected at low concentration, without the need for toxicity testing using animal studies. In this paper, the CoMSAS approach has been applied for elderberry and pumpkin NSEs used for food colouring purposes. Subject Life Triskelion BVRAPID - Risk Analysis for Products in Development ARPC - Analytical Research (Pharm & Chemistry)ELSS - Earth, Life and Social SciencesFood and NutritionNutritionHealthy LivingNon-selective extractSafetyComplex mixture safety assessmentStrategyThreshold of toxicological concernTTCProcessingAflatoxinAzoxy derivativeBiphenyl derivativeCarbamic acid derivativeChemical compoundDibenzodioxin derivativeDibenzofuran derivativeMiscellaneous drugs and agentsNitroso derivativeNon selective extractOrganophosphatePolymerProteinSemi volatile substanceSteroidSugarUnclassified drugVolatile agentWaterYoghurtallergenicityAnalysisAnalytical parametersAshChemical analysisChemistryComparative studyComplex mixture safety assessment strategyConcentration (parameters)Controlled studyDietary fiberDrug mixtureExposureFoodFood colorFood compositionFuit gumFruit juiceGenotoxicityHazard assessmentIce creamLiquid chromatographyLiquid liquid extractionMass fragmentographyMass fragmentographyNonhumanPrevention and controlProceduresRisk assessmentSambucusSoft drinkSolid phase extractionSolid phase microextractionSquashThreshold of toxicological concernToxicity testingChemistryComplex MixturesFood AnalysisFood ContaminationFood HandlingFood SafetyGas Chromatography-Mass SpectrometryHazard Analysis and Critical Control PointsHumansMethodsPrevention and controlToxicityAnimalia To reference this document use: http://resolver.tudelft.nl/uuid:a7800ad9-55d4-443f-a7f1-8f535884f344 DOI https://doi.org/10.1016/j.fct.2015.03.010 TNO identifier 523831 Source Food and Chemical Toxicology, 80, 163-181 Document type article Files To receive the publication files, please send an e-mail request to TNO Library.