Title
The effect of walking and vitamin B supplementation on quality of life in community-dwelling adults with mild cognitive impairment: A randomized, controlled trial
Author
van Uffelen, J.G.Z.
Chin A Paw, M.J.M.
Hopman-Rock, M.
van Mechelen, W.
TNO Kwaliteit van Leven
Publication year
2007
Abstract
Objectives: To examine the effect of walking and vitamin B supplementation on quality-of-life (QoL) in community-dwelling adults with mild cognitive impairment. Methods: One year, double-blind, placebo-controlled trial. Participants were randomized to: (1) twice-weekly, group-based, moderate-intensity walking program (n = 77) or a light-intensity placebo activity program (n = 75); and (2) daily vitamin B pills containing 5 mg folic acid, 0.4 mg B12, 50 mg B6 (n = 78) or placebo pills (n = 74). QoL was measured at baseline, after six and 12 months using the population-specific Dementia Quality-of-Life (D-QoL) to assess overall QoL and the generic Short-Form 12 mental and physical component scales (SF12-MCS and SF12-PCS) to assess health-related QoL. Results: Baseline levels of QoL were relatively high. Modified intention-to-treat analyses revealed no positive main intervention effect of walking or vitamin supplementation. In both men and women, ratings of D-QoL-belonging and D-QoL-positive affect subscales improved with 0.003 (P = 0.04) and 0.002 points (P = 0.06) with each percent increase in attendance to the walking program. Only in men, SF12-MCS increased with 0.03 points with each percent increase in attendance (P = 0.08). Conclusion: Several small but significant improvements in QoL were observed with increasing attendance to the walking program. No effect of vitamin B supplementation was observed. Trial Registration: International Standard Randomized Controlled Trial Number Register, 19227688, http://www.controlled-trials.com/isrctn/. © 2007 Springer Science+Business Media B.V.
Subject
Leefomgeving en gezondheid
Aged
Dietary supplements
Exercise
Quality of life
Randomized controlled trial
cyanocobalamin
folic acid
placebo
pyridoxine
vitamin B group
aged
article
clinical trial
cognitive defect
community
controlled clinical trial
controlled study
Dementia Quality of Life
disease severity
double blind procedure
drug effect
exercise
female
human
major clinical study
male
patient compliance
priority journal
quality of life
questionnaire
randomized controlled trial
Short Form 12
vitamin supplementation
walking
Aged
Aged, 80 and over
Cognition
Cognition Disorders
Community Health Services
Dementia
Dietary Supplements
Female
Health Surveys
Humans
Interviews
Male
Neuropsychological Tests
Nutritional Status
Program Evaluation
Psychometrics
Quality of Life
Questionnaires
Residence Characteristics
Treatment Outcome
Vitamin B Complex
Walking
To reference this document use:
http://resolver.tudelft.nl/uuid:a56d08dc-0c20-43d3-8212-03e0302e58ae
DOI
https://doi.org/10.1007/s11136-007-9219-z
TNO identifier
240178
Publisher
Springer
ISSN
0962-9343
Source
Quality of Life Research, 16 (7), 1137-1146
Document type
article