Title
Urinary CTX-II levels are associated with radiographic subtypes of osteoarthritis in hip, knee, hand, and facet joints in subject with familial osteoarthritis at multiple sites: The GARP study
Author
TNO Kwaliteit van Leven
Meulenbelt, I.
Kloppenburg, M.
Kroon, H.M.
Houwing-Duistermaat, J.J.
Garnero, P.
Hellio Le Graverand, M.P.
de Groot, J.
Slagboom, P.E.
Publication year
2006
Abstract
Objective: To assess the relation between the urinary concentrations of type II collagen C-telopeptide (UCTX-II) and radiographie signs of osteoarthritis (ROA) in the GARP (Genetics, Arthrosis and Progression) study. Methods: UCTX-II levels were measured in GARP study participants, who are sibling pairs predominantly with symptomatic osteoarthritis at multiple sites. Kellgren and Lawrence scores were used to assess ROA in the knees, hips, hands, and vertebral facet joints, and spinal disc degeneration. A proportionate score was made for each joint location, based on the number of joints with ROA. The sum total ROA score represents a measure of cartilage abnormalities within each patient. By using linear mixed models the total ROA score and the joint site specific ROA scores were correlated with the UCTX-II level. Results: In 302 subjects the mean (SD) and median (range) for UCTX-II were 265 (168) and 219 (1346) ng/mmol creatine, respectively. There was a significant association between the total ROA score and UCTX-II levels. Subsequent multivariate analysis showed that the joint site specific ROA score at all joint sites, except for spinal disc degeneration, contributed independently to this association. Conclusions: The total ROA score of GARP patients, representing cartilage abnormalities at the most prevalent ROA joint locations, showed an excellent correlation with UCTX-II levels. The specific ROA scores at the hip, hand, facet, and knee joints additively and independently explained this association. Even in patients with osteoarthritis at multiple sites, UCTX-II may be a sensitive quantitative marker of ROA. Chemicals / CAS: creatine, 57-00-1; Biological Markers; collagen type I trimeric cross-linked peptide; Collagen Type I; Collagen, 9007-34-5; PeptidesChemicals / CAS: creatine, 57-00-1; Biological Markers; collagen type I trimeric cross-linked peptide; Collagen Type I; Collagen, 9007-34-5; Peptides
Subject
Biomedical Research
carboxy terminal telopeptide
collagen type 2
creatine
articular cartilage
controlled study
familial disease
hand
hip
intervertebral disk degeneration
knee
major clinical study
radiography
risk factor
sibling
urinalysis
Adult
Aged
Arthrography
Biological Markers
Collagen
Collagen Type I
Female
Hand Joints
Humans
Male
Middle Aged
Osteoarthritis
Osteoarthritis, Hip
Osteoarthritis, Knee
Peptides
Risk Assessment
Severity of Illness Index
Zygapophyseal Joint
To reference this document use:
http://resolver.tudelft.nl/uuid:9d69959e-2194-418a-8b65-bfcd3b35adc2
DOI
https://doi.org/10.1136/ard.2005.040642
TNO identifier
239159
ISSN
0003-4967
Source
Annals of the Rheumatic Diseases, 65 (65), 360-365
Document type
article